BAIT
IRC21
YMR073C
Putative protein of unknown function; may be involved in resistance to carboplatin and cisplatin; null mutant displays increase in spontaneous Rad52p foci; contains a lipid-binding domain and binds cardiolipin in a large-scale study
GO Process (1)
GO Function (0)
GO Component (1)
Gene Ontology Biological Process
Saccharomyces cerevisiae (S288c)
PREY
STE20
mitogen-activated protein kinase kinase kinase kinase STE20, L000002123, YHL007C
Cdc42p-activated signal transducing kinase; involved in pheromone response, pseudohyphal/invasive growth, vacuole inheritance, down-regulation of sterol uptake; GBB motif binds Ste4p; member of the PAK (p21-activated kinase) family
GO Process (17)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
- activation of MAPKKK activity [IDA]
- bipolar cellular bud site selection [IGI, IMP]
- budding cell apical bud growth [IGI, IMP]
- cellular bud site selection [IMP]
- cellular response to heat [IMP]
- invasive growth in response to glucose limitation [IMP]
- negative regulation of gene expression [IGI, IMP]
- osmosensory signaling pathway via Sho1 osmosensor [IGI, IMP]
- pheromone-dependent signal transduction involved in conjugation with cellular fusion [IGI, IMP]
- positive regulation of apoptotic process [IMP]
- protein phosphorylation [IDA]
- pseudohyphal growth [IMP]
- regulation of exit from mitosis [IMP]
- signal transduction involved in filamentous growth [IMP]
- sterol import [IMP]
- stress granule assembly [IGI, IMP]
- vacuole inheritance [IGI, IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
Negative Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
PP2A Controls Genome Integrity by Integrating Nutrient-Sensing and Metabolic Pathways with the DNA Damage Response.
Mec1(ATR) mediates the DNA damage response (DDR), integrating chromosomal signals and mechanical stimuli. We show that the PP2A phosphatases, ceramide-activated enzymes, couple cell metabolism with the DDR. Using genomic screens, metabolic analysis, and genetic and pharmacological studies, we found that PP2A attenuates the DDR and that three metabolic circuits influence the DDR by modulating PP2A activity. Irc21, a putative cytochrome ... [more]
Mol. Cell Jul. 20, 2017; 67(2);266-281.e4 [Pubmed: 28648781]
Throughput
- High Throughput
Ontology Terms
- phenotype: vegetative growth (APO:0000106)
Curated By
- BioGRID