HHF2
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
IPL1
Gene Ontology Biological Process
- attachment of spindle microtubules to kinetochore [IMP]
- chromosome segregation [IMP]
- homologous chromosome segregation [IMP]
- meiotic sister chromatid segregation [IMP]
- mitotic DNA integrity checkpoint [IGI]
- mitotic spindle disassembly [IMP]
- negative regulation of protein import into nucleus during spindle assembly checkpoint [IMP]
- positive regulation of spindle checkpoint [IMP]
- protein phosphorylation [IDA, IMP]
- regulation of cytokinesis [IMP]
- regulation of spindle assembly involved in mitosis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Phenotypic Suppression
A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Defective histone supply causes condensin-dependent chromatin alterations, SAC activation and chromosome decatenation impairment.
The structural organization of chromosomes is essential for their correct function and dynamics during the cell cycle. The assembly of DNA into chromatin provides the substrate for topoisomerases and condensins, which introduce the different levels of superhelical torsion required for DNA metabolism. In particular, Top2 and condensin are directly involved in both the resolution of precatenanes that form during replication ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: cell cycle progression (APO:0000253)
Additional Notes
- Figure 3A
- ipl1-321 mutation prevents mitotic arrest induced by HHF2-depletion
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
IPL1 HHF2 | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 1238458 | |
HHF2 IPL1 | Synthetic Growth Defect Synthetic Growth Defect A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell. | Low | - | BioGRID | 2354876 | |
IPL1 HHF2 | Synthetic Growth Defect Synthetic Growth Defect A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell. | Low | - | BioGRID | 1238455 | |
IPL1 HHF2 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | BioGRID | 1238453 |
Curated By
- BioGRID