BAIT
SSN8
CNC1, GIG3, NUT9, RYE2, SRB11, UME3, CycC, L000002796, YNL025C
Cyclin-like component of the RNA polymerase II holoenzyme; involved in phosphorylation of the RNA polymerase II C-terminal domain; forms a kinase-cyclin pair in the RNAPII holoenzyme with Ssn3p; required for both entry into and execution of the meiotic program; involved in glucose repression and telomere maintenance; cyclin homolog 35% identical to human cyclin C
GO Process (4)
GO Function (1)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
PREY
ARG82
ARGR3, IPK2, inositol polyphosphate multikinase, ARGRIII, L000002727, YDR173C
Inositol polyphosphate multikinase (IPMK); sequentially phosphorylates Ins(1,4,5)P3 to form Ins(1,3,4,5,6)P5; also has diphosphoinositol polyphosphate synthase activity; regulates arginine-, phosphate-, and nitrogen-responsive genes
GO Process (6)
GO Function (7)
GO Component (1)
Gene Ontology Biological Process
- inositol phosphate biosynthetic process [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- phosphatidylinositol phosphorylation [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- protein stabilization [IMP]
- regulation of arginine metabolic process [IMP]
Gene Ontology Molecular Function- inositol tetrakisphosphate 3-kinase activity [IDA]
- inositol tetrakisphosphate 6-kinase activity [IDA]
- inositol-1,3,4,5,6-pentakisphosphate kinase activity [IDA]
- inositol-1,4,5-trisphosphate 3-kinase activity [IMP]
- inositol-1,4,5-trisphosphate 6-kinase activity [IDA]
- phosphatidylinositol 3-kinase activity [IDA]
- protein binding, bridging [IMP, IPI]
- inositol tetrakisphosphate 3-kinase activity [IDA]
- inositol tetrakisphosphate 6-kinase activity [IDA]
- inositol-1,3,4,5,6-pentakisphosphate kinase activity [IDA]
- inositol-1,4,5-trisphosphate 3-kinase activity [IMP]
- inositol-1,4,5-trisphosphate 6-kinase activity [IDA]
- phosphatidylinositol 3-kinase activity [IDA]
- protein binding, bridging [IMP, IPI]
Saccharomyces cerevisiae (S288c)
Negative Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
A Network of Conserved Synthetic Lethal Interactions for Exploration of Precision Cancer Therapy.
An emerging therapeutic strategy for cancer is to induce selective lethality in a tumor by exploiting interactions between its driving mutations and specific drug targets. Here we use a multi-species approach to develop a resource of synthetic lethal interactions relevant to cancer therapy. First, we screen in yeast ∼169,000 potential interactions among orthologs of human tumor suppressor genes (TSG) and ... [more]
Mol. Cell Aug. 04, 2016; 63(3);514-25 [Pubmed: 27453043]
Quantitative Score
- -2.57 [Confidence Score]
Throughput
- High Throughput
Ontology Terms
- phenotype: colony size (APO:0000063)
Additional Notes
- Untreated conditions. SGA was used to score genetic interactions based on the colony size of double versus single mutants. Genetic interactions were considered significant if they had an S score >= 2.0 for positive interactions (epistatic or suppressor interactions) and S score <= -2.5 for negative interactions (synthetic sick/lethal interactions).
Curated By
- BioGRID