TOP2
Gene Ontology Biological Process
- DNA strand elongation involved in DNA replication [IMP]
- DNA topological change [IDA]
- DNA unwinding involved in DNA replication [IMP]
- chromatin assembly or disassembly [IMP]
- chromatin remodeling at centromere [IMP]
- mitotic DNA integrity checkpoint [IMP]
- reciprocal meiotic recombination [IMP]
- regulation of mitotic recombination [IMP]
- replication fork progression beyond termination site [IMP]
- resolution of meiotic recombination intermediates [IBA]
- sister chromatid segregation [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ESC1
Gene Ontology Biological Process
Gene Ontology Cellular Component
Phenotypic Suppression
A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Chromosome length and perinuclear attachment constrain resolution of DNA intertwines.
To allow chromosome segregation, topoisomerase II (topo II) must resolve sister chromatid intertwines (SCI) formed during deoxynucleic acid (DNA) replication. How this process extends to the full genome is not well understood. In budding yeast, the unique structure of the ribosomal DNA (rDNA) array is thought to cause late SCI resolution of this genomic region during anaphase. In this paper, ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: chromosome segregation (APO:0000208)
Additional Notes
- Figure 5
- LYS4 separation and segregation defects
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
TOP2 ESC1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.298 | BioGRID | 2008860 |
Curated By
- BioGRID