SLX4
Gene Ontology Biological Process
- DNA catabolic process, endonucleolytic [ISO]
- DNA double-strand break processing involved in repair via single-strand annealing [ISO]
- DNA repair [ISO]
- double-strand break repair via homologous recombination [ISO]
- nucleotide-excision repair [ISO]
- positive regulation of catalytic activity [ISO]
- response to intra-S DNA damage checkpoint signaling [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ERCC1
Gene Ontology Biological Process
- DNA catabolic process, endonucleolytic [ISO]
- DNA recombination [IMP, ISO]
- DNA repair [IMP]
- UV protection [IMP]
- cell development [IMP]
- cell proliferation [IMP]
- cellular response to DNA damage stimulus [IMP]
- chromosome organization [IMP]
- double-strand break repair [IMP]
- germ cell development [IMP]
- interstrand cross-link repair [IMP]
- isotype switching [IMP]
- male gonad development [IMP]
- mitotic recombination [ISO]
- multicellular organism growth [IGI, IMP]
- multicellular organismal aging [IMP]
- negative regulation of telomere maintenance [ISO]
- nucleotide-excision repair [IMP, ISO]
- nucleotide-excision repair, DNA incision, 3'-to lesion [ISO]
- nucleotide-excision repair, DNA incision, 5'-to lesion [ISO]
- oogenesis [IMP]
- post-embryonic hemopoiesis [IMP]
- pyrimidine dimer repair by nucleotide-excision repair [IMP]
- replicative cell aging [IMP]
- response to X-ray [IMP]
- response to oxidative stress [ISO]
- spermatogenesis [IMP]
- syncytium formation [IMP]
Gene Ontology Molecular Function- TBP-class protein binding [IPI]
- TFIID-class transcription factor binding [IDA]
- damaged DNA binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- single-stranded DNA binding [ISO]
- single-stranded DNA endodeoxyribonuclease activity [ISO]
- structure-specific DNA binding [ISO]
- TBP-class protein binding [IPI]
- TFIID-class transcription factor binding [IDA]
- damaged DNA binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- single-stranded DNA binding [ISO]
- single-stranded DNA endodeoxyribonuclease activity [ISO]
- structure-specific DNA binding [ISO]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Disruption of mouse Slx4, a regulator of structure-specific nucleases, phenocopies Fanconi anemia.
The evolutionarily conserved SLX4 protein, a key regulator of nucleases, is critical for DNA damage response. SLX4 nuclease complexes mediate repair during replication and can also resolve Holliday junctions formed during homologous recombination. Here we describe the phenotype of the Btbd12 knockout mouse, the mouse ortholog of SLX4, which recapitulates many key features of the human genetic illness Fanconi anemia. ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SLX4 ERCC1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| SLX4 ERCC1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | 1515240 | |
| ERCC1 SLX4 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | 1515242 | |
| SLX4 ERCC1 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID