PDGFRA
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- cardiac myofibril assembly [ISS]
- cell activation [TAS]
- cell chemotaxis [IMP]
- embryonic cranial skeleton morphogenesis [ISS]
- embryonic digestive tract morphogenesis [ISS]
- embryonic skeletal system morphogenesis [ISS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- luteinization [ISS]
- metanephric glomerular capillary formation [ISS]
- negative regulation of platelet activation [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- peptidyl-tyrosine phosphorylation [IDA]
- phosphatidylinositol-mediated signaling [IMP, TAS]
- platelet aggregation [IMP]
- platelet-derived growth factor receptor signaling pathway [IDA]
- platelet-derived growth factor receptor-alpha signaling pathway [IMP]
- positive regulation of DNA replication [IDA]
- positive regulation of ERK1 and ERK2 cascade [IMP]
- positive regulation of cell migration [IDA, IMP]
- positive regulation of cell proliferation [IMP]
- positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway [IDA]
- positive regulation of cytosolic calcium ion concentration [IMP]
- positive regulation of fibroblast proliferation [IDA]
- positive regulation of phosphatidylinositol 3-kinase activity [IMP]
- positive regulation of phosphatidylinositol 3-kinase signaling [TAS]
- positive regulation of phospholipase C activity [IMP]
- protein autophosphorylation [IDA]
- regulation of actin cytoskeleton reorganization [TAS]
- regulation of chemotaxis [IMP]
- regulation of mesenchymal stem cell differentiation [IMP]
- retina vasculature development in camera-type eye [ISS]
- wound healing [ISS]
Gene Ontology Molecular Function- platelet-derived growth factor alpha-receptor activity [IDA, IMP]
- platelet-derived growth factor binding [IDA, IPI]
- platelet-derived growth factor receptor binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- transmembrane receptor protein tyrosine kinase activity [IDA]
- vascular endothelial growth factor binding [IPI]
- vascular endothelial growth factor-activated receptor activity [IDA]
- platelet-derived growth factor alpha-receptor activity [IDA, IMP]
- platelet-derived growth factor binding [IDA, IPI]
- platelet-derived growth factor receptor binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- transmembrane receptor protein tyrosine kinase activity [IDA]
- vascular endothelial growth factor binding [IPI]
- vascular endothelial growth factor-activated receptor activity [IDA]
Gene Ontology Cellular Component
PIK3CA
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- T cell costimulation [TAS]
- T cell receptor signaling pathway [TAS]
- blood coagulation [TAS]
- cardiac muscle contraction [TAS]
- endothelial cell migration [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- insulin receptor signaling pathway [TAS]
- insulin receptor signaling pathway via phosphatidylinositol 3-kinase [TAS]
- leukocyte migration [TAS]
- negative regulation of anoikis [IMP]
- neurotrophin TRK receptor signaling pathway [TAS]
- phosphatidylinositol biosynthetic process [TAS]
- phosphatidylinositol phosphorylation [ISS]
- phosphatidylinositol-mediated signaling [TAS]
- phospholipid metabolic process [TAS]
- platelet activation [TAS]
- small molecule metabolic process [TAS]
- vasculature development [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Phospholipase C-gamma 1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal.
Upon ligand-induced tyrosine phosphorylation, the platelet-derived growth factor (PDGF) receptor (PDGFR) beta subunit associates with PLC-gamma 1, RasGAP, P13K, and a 64 kd protein. To determine the relative role of each of these associated proteins in PDGFR signaling, we constructed a PDGFR mutant (F5) unable to bind any of them and a panel of "add-back" mutants that could bind only ... [more]
Throughput
- Low Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
PDGFRA PIK3CA | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID