FKBP1B
Gene Ontology Biological Process
- 'de novo' protein folding [TAS]
- calcium ion transmembrane transport [TAS]
- calcium-mediated signaling using intracellular calcium source [TAS]
- cell communication by electrical coupling involved in cardiac conduction [TAS]
- chaperone-mediated protein folding [IBA]
- cytosolic calcium ion homeostasis [IDA, IGI]
- negative regulation of heart rate [ISS]
- negative regulation of protein phosphatase type 2B activity [IDA]
- negative regulation of release of sequestered calcium ion into cytosol [IDA]
- negative regulation of ryanodine-sensitive calcium-release channel activity [IDA]
- positive regulation of sequestering of calcium ion [IDA]
- protein maturation by protein folding [TAS]
- protein peptidyl-prolyl isomerization [IDA]
- protein refolding [TAS]
- regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [IBA, ISS]
- regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [IDA]
- regulation of ryanodine-sensitive calcium-release channel activity [IDA, IMP]
- response to redox state [IDA]
Gene Ontology Molecular Function
RYR2
Gene Ontology Biological Process
- Purkinje myocyte to ventricular cardiac muscle cell signaling [ISS]
- calcium ion transport [IDA]
- calcium ion transport into cytosol [IDA]
- calcium-mediated signaling [ISS]
- calcium-mediated signaling using intracellular calcium source [IDA]
- cardiac muscle contraction [IMP]
- cardiac muscle hypertrophy [ISS]
- cell communication by electrical coupling involved in cardiac conduction [IC]
- cellular calcium ion homeostasis [ISS]
- cellular response to caffeine [IDA, ISS]
- cellular response to epinephrine stimulus [TAS]
- cytosolic calcium ion homeostasis [ISS]
- detection of calcium ion [IDA]
- embryonic heart tube morphogenesis [ISS]
- establishment of protein localization to endoplasmic reticulum [IDA]
- ion transmembrane transport [TAS]
- left ventricular cardiac muscle tissue morphogenesis [ISS]
- positive regulation of calcium-transporting ATPase activity [IDA]
- positive regulation of heart rate [ISS]
- positive regulation of ryanodine-sensitive calcium-release channel activity by adrenergic receptor signaling pathway involved in positive regulation of cardiac muscle contraction [ISS]
- positive regulation of sequestering of calcium ion [IDA]
- positive regulation of the force of heart contraction [IMP]
- regulation of cardiac muscle contraction [IMP]
- regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [IC, ISS]
- regulation of heart rate [IMP]
- release of sequestered calcium ion into cytosol [IDA, ISS]
- release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [IMP, ISS]
- response to caffeine [IDA]
- response to hypoxia [ISS]
- response to muscle stretch [IMP]
- response to redox state [IDA]
- sarcoplasmic reticulum calcium ion transport [TAS]
- transmembrane transport [TAS]
- type B pancreatic cell apoptotic process [IMP]
- ventricular cardiac muscle cell action potential [ISS]
Gene Ontology Molecular Function- calcium channel activity [ISS]
- calcium-induced calcium release activity [IDA]
- calcium-release channel activity [IDA]
- calmodulin binding [IMP, IPI, ISS]
- enzyme binding [IPI]
- identical protein binding [IPI]
- intracellular ligand-gated calcium channel activity [ISS]
- ion channel binding [ISS]
- protein binding [IPI]
- protein kinase A catalytic subunit binding [IDA]
- protein kinase A regulatory subunit binding [IDA]
- ryanodine-sensitive calcium-release channel activity [IDA]
- suramin binding [IMP]
- calcium channel activity [ISS]
- calcium-induced calcium release activity [IDA]
- calcium-release channel activity [IDA]
- calmodulin binding [IMP, IPI, ISS]
- enzyme binding [IPI]
- identical protein binding [IPI]
- intracellular ligand-gated calcium channel activity [ISS]
- ion channel binding [ISS]
- protein binding [IPI]
- protein kinase A catalytic subunit binding [IDA]
- protein kinase A regulatory subunit binding [IDA]
- ryanodine-sensitive calcium-release channel activity [IDA]
- suramin binding [IMP]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Localization of the dantrolene-binding sequence near the FK506-binding protein-binding site in the three-dimensional structure of the ryanodine receptor.
Dantrolene is believed to stabilize interdomain interactions between the NH2-terminal and central regions of ryanodine receptors by binding to the NH2-terminal residues 590-609 in skeletal ryanodine receptor (RyR1) and residues 601-620 in cardiac ryanodine receptor (RyR2). To gain further insight into the structural basis of dantrolene action, we have attempted to localize the dantrolene-binding sequence in RyR1/RyR2 by using GFP ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| FKBP1B RYR2 | FRET FRET An interaction is inferred when close proximity of interaction partners is detected by fluorescence resonance energy transfer between pairs of fluorophore-labeled molecules, such as occurs between CFP (donor) and YFP (acceptor) fusion proteins. | Low | - | BioGRID | - | |
| FKBP1B RYR2 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - |
Curated By
- BioGRID