MIH1
Gene Ontology Biological Process
Gene Ontology Molecular Function
RTS1
Gene Ontology Biological Process
- cellular bud neck septin ring organization [IGI, IMP]
- cellular protein localization [IMP]
- establishment of protein localization to chromosome [IMP]
- meiotic sister chromatid cohesion, centromeric [IMP]
- mitotic spindle orientation checkpoint [IGI]
- protein dephosphorylation [IDA, IMP]
- septin ring disassembly [IMP]
- sister chromatid biorientation [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Redundant Regulation of Cdk1 Tyrosine Dephosphorylation in Saccharomyces cerevisiae.
Cdk1 activity drives both mitotic entry and the metaphase-to-anaphase transition in all eukaryotes. The kinase Wee1, and the phosphatase Cdc25, regulate the mitotic activity of Cdk1 by the reversible phosphorylation of a conserved tyrosine residue. Mutation of cdc25 in Schizosaccharomyces pombe blocks Cdk1 dephosphorylation and causes cell cycle arrest. In contrast, deletion of MIH1, the cdc25 homologue in Saccharomyces cerevisiae, ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Additional Notes
- genetic complex
- mih1 ptp1 rts1 triple mutant
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
RTS1 MIH1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.1409 | BioGRID | 414088 | |
MIH1 RTS1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.4772 | BioGRID | 2161242 | |
RTS1 MIH1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.1257 | BioGRID | 2181560 | |
MIH1 RTS1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.5267 | BioGRID | 2432328 |
Curated By
- BioGRID