BAIT

DOK1

P62DOK
docking protein 1, 62kDa (downstream of tyrosine kinase 1)
GO Process (4)
GO Function (1)
GO Component (3)
Homo sapiens
PREY

ITGB3

BDPLT16, BDPLT2, CD61, GP3A, GPIIIa, GT
integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
GO Process (36)
GO Function (9)
GO Component (16)
Homo sapiens

Reconstituted Complex

An interaction is detected between purified proteins in vitro.

Publication

Beta integrin tyrosine phosphorylation is a conserved mechanism for regulating talin-induced integrin activation.

Anthis NJ, Haling JR, Oxley CL, Memo M, Wegener KL, Lim CJ, Ginsberg MH, Campbell ID

Integrins are large membrane-spanning receptors fundamental to cell adhesion and migration. Integrin adhesiveness for the extracellular matrix is activated by the cytoskeletal protein talin via direct binding of its phosphotyrosine-binding-like F3 domain to the cytoplasmic tail of the beta integrin subunit. The phosphotyrosine-binding domain of the signaling protein Dok1, on the other hand, has an inactivating effect on integrins, a ... [more]

J. Biol. Chem. Dec. 25, 2009; 284(52);36700-10 [Pubmed: 19843520]

Throughput

  • Low Throughput

Curated By

  • BioGRID