BAIT

CYTH2

ARNO, CTS18, CTS18.1, PSCD2, PSCD2L, SEC7L, Sec7p-L, Sec7p-like
cytohesin 2
Homo sapiens
PREY

ARL4A

ARL4
ADP-ribosylation factor-like 4A
GO Process (0)
GO Function (2)
GO Component (3)

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

ARL4D recruits cytohesin-2/ARNO to modulate actin remodeling.

Li CC, Chiang TC, Wu TS, Pacheco-Rodriguez G, Moss J, Lee FJ

ARL4D is a developmentally regulated member of the ADP-ribosylation factor/ARF-like protein (ARF/ARL) family of Ras-related GTPases. Although the primary structure of ARL4D is very similar to that of other ARF/ARL molecules, its function remains unclear. Cytohesin-2/ARF nucleotide-binding-site opener (ARNO) is a guanine nucleotide-exchange factor (GEF) for ARF, and, at the plasma membrane, it can activate ARF6 to regulate actin reorganization ... [more]

Mol. Biol. Cell Nov. 01, 2007; 18(11);4420-37 [Pubmed: 17804820]

Throughput

  • Low Throughput

Curated By

  • BioGRID