BAIT

PMI40

mannose-6-phosphate isomerase PMI40, PMI, L000001452, YER003C
Mannose-6-phosphate isomerase; catalyzes the interconversion of fructose-6-P and mannose-6-P; required for early steps in protein mannosylation
GO Process (3)
GO Function (1)
GO Component (2)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)
PREY

IRE1

ERN1, bifunctional endoribonuclease/protein kinase IRE1, L000000875, YHR079C
Serine-threonine kinase and endoribonuclease; transmembrane protein that mediates the unfolded protein response (UPR) by regulating Hac1p synthesis through HAC1 mRNA splicing; role in homeostatic adaptation to ER stress; Kar2p binds inactive Ire1p and releases from it upon ER stress
Kinome Project (Sc)
Saccharomyces cerevisiae (S288c)

Phenotypic Suppression

A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Publication

Role of the unfolded protein response in regulating the mucin-dependent filamentous-growth mitogen-activated protein kinase pathway.

Adhikari H, Vadaie N, Chow J, Caccamise LM, Chavel CA, Li B, Bowitch A, Stefan CJ, Cullen PJ

Signaling mucins are evolutionarily conserved regulators of signal transduction pathways. The signaling mucin Msb2p regulates the Cdc42p-dependent mitogen-activated protein kinase (MAPK) pathway that controls filamentous growth in yeast. The cleavage and release of the glycosylated inhibitory domain of Msb2p is required for MAPK activation. We show here that proteolytic processing of Msb2p was induced by underglycosylation of its extracellular domain. ... [more]

Mol. Cell. Biol. Apr. 01, 2015; 35(8);1414-32 [Pubmed: 25666509]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: protein activity (APO:0000022)
  • phenotype: protein/peptide modification (APO:0000131)

Additional Notes

  • Figure 2
  • pmi40-101

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
PMI40 IRE1
Negative Genetic
Negative Genetic

Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.

High-0.639BioGRID
1975399

Curated By

  • BioGRID