PDGFRB
Gene Ontology Biological Process
- adrenal gland development [IGI]
- aorta morphogenesis [IGI]
- cardiac myofibril assembly [IGI]
- cardiac vascular smooth muscle cell differentiation [TAS]
- cell chemotaxis [ISO]
- cell migration [ISO]
- cell migration involved in coronary angiogenesis [IMP]
- cell migration involved in vasculogenesis [IMP]
- cellular response to platelet-derived growth factor stimulus [ISO]
- glycosaminoglycan biosynthetic process [ISO]
- hemopoiesis [IMP]
- in utero embryonic development [IMP]
- intracellular signal transduction [ISO]
- kidney development [IMP]
- metanephric glomerular capillary formation [IGI]
- metanephric glomerular mesangial cell proliferation involved in metanephros development [IMP]
- metanephric mesenchymal cell migration [ISO]
- negative regulation of apoptotic process [ISO]
- nitrogen compound metabolic process [IMP]
- peptidyl-tyrosine phosphorylation [IDA, ISO]
- phosphatidylinositol metabolic process [ISO]
- phosphatidylinositol-mediated signaling [ISO]
- phosphorylation [IMP]
- platelet-derived growth factor receptor signaling pathway [IMP, ISO]
- platelet-derived growth factor receptor-beta signaling pathway [ISO]
- positive regulation of DNA biosynthetic process [IMP]
- positive regulation of ERK1 and ERK2 cascade [IDA, IMP, ISO]
- positive regulation of MAP kinase activity [IDA]
- positive regulation of calcium ion import [IMP]
- positive regulation of cell migration [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway [ISO]
- positive regulation of chemotaxis [IDA]
- positive regulation of collagen biosynthetic process [ISO]
- positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway [IMP]
- positive regulation of mitosis [IDA]
- positive regulation of phosphatidylinositol 3-kinase activity [ISO]
- positive regulation of phosphatidylinositol 3-kinase signaling [IDA]
- positive regulation of phospholipase C activity [ISO]
- positive regulation of phosphoprotein phosphatase activity [ISO]
- positive regulation of reactive oxygen species metabolic process [IMP]
- positive regulation of smooth muscle cell migration [IGI, IMP, ISO]
- positive regulation of smooth muscle cell proliferation [IMP, ISO]
- protein autophosphorylation [IDA, ISO]
- regulation of actin cytoskeleton organization [IGI]
- regulation of peptidyl-tyrosine phosphorylation [IMP]
- retina vasculature development in camera-type eye [IGI, IMP]
- signal transduction [IDA, ISO]
- skeletal system morphogenesis [IMP]
- smooth muscle cell chemotaxis [IGI]
- smooth muscle tissue development [IMP]
- tissue homeostasis [IMP]
Gene Ontology Molecular Function- kinase activity [IMP]
- phosphatidylinositol 3-kinase binding [ISO]
- platelet-derived growth factor beta-receptor activity [ISO]
- platelet-derived growth factor binding [ISO, TAS]
- platelet-derived growth factor receptor binding [ISO]
- platelet-derived growth factor-activated receptor activity [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- protein tyrosine kinase activity [ISO]
- receptor binding [IPI, ISO]
- signal transducer activity [IDA]
- vascular endothelial growth factor binding [ISO]
- kinase activity [IMP]
- phosphatidylinositol 3-kinase binding [ISO]
- platelet-derived growth factor beta-receptor activity [ISO]
- platelet-derived growth factor binding [ISO, TAS]
- platelet-derived growth factor receptor binding [ISO]
- platelet-derived growth factor-activated receptor activity [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- protein tyrosine kinase activity [ISO]
- receptor binding [IPI, ISO]
- signal transducer activity [IDA]
- vascular endothelial growth factor binding [ISO]
Gene Ontology Cellular Component
PLCG1
Gene Ontology Biological Process
- T cell receptor signaling pathway [IDA]
- calcium ion transport [ISO]
- calcium-mediated signaling [ISO]
- cell migration [ISO]
- cellular response to epidermal growth factor stimulus [ISO]
- epidermal growth factor receptor signaling pathway [ISO]
- in utero embryonic development [IMP]
- inositol trisphosphate biosynthetic process [ISO]
- positive regulation of angiogenesis [ISO]
- positive regulation of blood vessel endothelial cell migration [ISO]
- positive regulation of epithelial cell migration [ISO]
- positive regulation of release of sequestered calcium ion into cytosol [ISO]
- protein secretion [ISO]
- regulation of store-operated calcium channel activity [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
A single amino acid substitution in a WW-like domain of diverse members of the PDGF receptor subfamily of tyrosine kinases causes constitutive receptor activation.
Platelet-derived growth factor beta receptor (PDGFbetaR) is a transmembrane receptor tyrosine kinase involved in a variety of cellular functions. We have generated a constitutively activated murine PDGFbetaR containing a valine to alanine substitution at residue 536, located in the cytoplasmic juxtamembrane domain. When this mutant receptor (PR-V536A) was expressed in Ba/F3 cells, it allowed the cells to survive and proliferate ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PLCG1 PDGFRB | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | Low | - | BioGRID | - |
Curated By
- BioGRID