BAIT

YAP1

PAR1, SNQ3, DNA-binding transcription factor YAP1, L000001364, YML007W

Basic leucine zipper (bZIP) transcription factor; required for oxidative stress tolerance; activated by H2O2 through the multistep formation of disulfide bonds and transit from the cytoplasm to the nucleus; Yap1p is degraded in the nucleus after the oxidative stress has passed; mediates resistance to cadmium; relative distribution to the nucleus increases upon DNA replication stress; YAP1 has a paralog, CAD1, that arose from the whole genome duplication

GO Process (6)

GO Function (2)

GO Component (2)

Gene Ontology Biological Process

positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance [IMP]

regulation of transcription from RNA polymerase II promoter in response to oxidative stress [IDA]

response to drug [IMP]

response to heat [IMP]

response to metal ion [IMP]

response to singlet oxygen [IMP]

Gene Ontology Molecular Function

sequence-specific DNA binding [IDA]
sequence-specific DNA binding transcription factor activity [IDA]

Gene Ontology Cellular Component

cytoplasm [IDA]

nucleus [IDA]

SGD Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Saccharomyces cerevisiae (S288c)

PREY

ARR1

ACR1, YAP8, L000004292, YPR199C

Transcriptional activator of the basic leucine zipper (bZIP) family; required for transcription of genes involved in resistance to arsenic compounds

GO Process (1)

GO Function (3)

GO Component (2)

Gene Ontology Biological Process

positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance [IGI, IMP]

Gene Ontology Molecular Function

DNA binding [IDA]
RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA, IMP]

Gene Ontology Cellular Component

cytoplasm [IDA]

nucleus [IDA]

SGD Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Saccharomyces cerevisiae (S288c)

Phenotypic Enhancement

A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Publication

The MAPK Hog1p modulates Fps1p-dependent arsenite uptake and tolerance in yeast.

Thorsen M, Di Y, Taengemo C, Morillas M, Ahmadpour D, Van der Does C, Wagner A, Johansson E, Boman J, Posas F, Wysocki R, Tamas MJ

Arsenic is widely distributed in nature and all organisms possess regulatory mechanisms to evade toxicity and acquire tolerance. Yet, little is known about arsenic sensing and signaling mechanisms or about their impact on tolerance and detoxification systems. Here, we describe a novel role of the S. cerevisiae mitogen-activated protein kinase Hog1p in protecting cells during exposure to arsenite and the ... [more]

Mol. Biol. Cell Oct. 01, 2006; 17(10);4400-10 [Pubmed: 16885417]

Throughput

Low Throughput

Ontology Terms

resistance to chemicals (APO:0000087)

Additional Notes

double mutants show increased sensitivity to metalloids

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
YAP1 ARR1	Dosage Rescue Dosage Rescue A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene.	Menezes RA (2008)	Low	-	BioGRID	298296
YAP1 ARR1	Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.	Ilina Y (2008)	Low	-	BioGRID	329921
YAP1 ARR1	Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.	Menezes RA (2008)	Low	-	BioGRID	298297
YAP1 ARR1	Synthetic Growth Defect Synthetic Growth Defect A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.	da Silva SM (2018)	Low	-	BioGRID	2454868
YAP1 ARR1	Synthetic Growth Defect Synthetic Growth Defect A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.	Wysocki R (2004)	Low	-	BioGRID	157454

Curated By

BioGRID

Interaction Summary

YAP1

Gene Ontology Biological Process

Gene Ontology Molecular Function

sequence-specific DNA binding [IDA]sequence-specific DNA binding transcription factor activity [IDA]

Gene Ontology Cellular Component

ARR1

Gene Ontology Biological Process

Gene Ontology Molecular Function

DNA binding [IDA]RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA, IMP]

Gene Ontology Cellular Component

Phenotypic Enhancement

Publication

The MAPK Hog1p modulates Fps1p-dependent arsenite uptake and tolerance in yeast.

Throughput

Ontology Terms

Additional Notes

Related interactions

Curated By

sequence-specific DNA binding [IDA]
sequence-specific DNA binding transcription factor activity [IDA]

DNA binding [IDA]
RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA, IMP]