BAIT

YAP1

PAR1, SNQ3, DNA-binding transcription factor YAP1, L000001364, YML007W

Basic leucine zipper (bZIP) transcription factor; required for oxidative stress tolerance; activated by H2O2 through the multistep formation of disulfide bonds and transit from the cytoplasm to the nucleus; Yap1p is degraded in the nucleus after the oxidative stress has passed; mediates resistance to cadmium; relative distribution to the nucleus increases upon DNA replication stress; YAP1 has a paralog, CAD1, that arose from the whole genome duplication

GO Process (6)

GO Function (2)

GO Component (2)

Gene Ontology Biological Process

positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance [IMP]

regulation of transcription from RNA polymerase II promoter in response to oxidative stress [IDA]

response to drug [IMP]

response to heat [IMP]

response to metal ion [IMP]

response to singlet oxygen [IMP]

Gene Ontology Molecular Function

sequence-specific DNA binding [IDA]
sequence-specific DNA binding transcription factor activity [IDA]

Gene Ontology Cellular Component

cytoplasm [IDA]

nucleus [IDA]

SGD Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Saccharomyces cerevisiae (S288c)

PREY

ARR1

ACR1, YAP8, L000004292, YPR199C

Transcriptional activator of the basic leucine zipper (bZIP) family; required for transcription of genes involved in resistance to arsenic compounds

GO Process (1)

GO Function (3)

GO Component (2)

Gene Ontology Biological Process

positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance [IGI, IMP]

Gene Ontology Molecular Function

DNA binding [IDA]
RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA, IMP]

Gene Ontology Cellular Component

cytoplasm [IDA]

nucleus [IDA]

SGD Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Saccharomyces cerevisiae (S288c)

Synthetic Growth Defect

A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.

Publication

Transcriptional regulation of FeS biogenesis genes: A possible shield against arsenate toxicity activated by Yap1.

da Silva SM, Batista-Nascimento L, Gaspar-Cordeiro A, Vernis L, Pimentel C, Rodrigues-Pousada C

In the eukaryotic model yeast Saccharomyces cerevisiae, arsenic (As) detoxification is regulated by two transcriptional factors, Yap8 and Yap1. Yap8 specifically controls As extrusion from the cell, whether Yap1 avoids arsenic-induced oxidative damages. Accordingly, cells lacking both Yap1 and Yap8 are more sensitive to arsenate than cells lacking each regulator individually. Strikingly enough, the same sensitivity pattern was observed under ... [more]

Biochim. Biophys. Acta Jul. 17, 2018; 1862(10);2152-2161 [Pubmed: 30025855]

Throughput

Low Throughput

Ontology Terms

vegetative growth (APO:0000106)
resistance to chemicals (APO:0000087)

Additional Notes

double mutants show increased sensitivity to arsenate

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
YAP1 ARR1	Dosage Rescue Dosage Rescue A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene.	Menezes RA (2008)	Low	-	BioGRID	298296
YAP1 ARR1	Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.	Ilina Y (2008)	Low	-	BioGRID	329921
YAP1 ARR1	Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.	Menezes RA (2008)	Low	-	BioGRID	298297
YAP1 ARR1	Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.	Thorsen M (2006)	Low	-	BioGRID	238199
YAP1 ARR1	Synthetic Growth Defect Synthetic Growth Defect A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.	Wysocki R (2004)	Low	-	BioGRID	157454

Curated By

BioGRID

Interaction Summary

YAP1

Gene Ontology Biological Process

Gene Ontology Molecular Function

sequence-specific DNA binding [IDA]sequence-specific DNA binding transcription factor activity [IDA]

Gene Ontology Cellular Component

ARR1

Gene Ontology Biological Process

Gene Ontology Molecular Function

DNA binding [IDA]RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA, IMP]

Gene Ontology Cellular Component

Synthetic Growth Defect

Publication

Transcriptional regulation of FeS biogenesis genes: A possible shield against arsenate toxicity activated by Yap1.

Throughput

Ontology Terms

Additional Notes

Related interactions

Curated By

sequence-specific DNA binding [IDA]
sequence-specific DNA binding transcription factor activity [IDA]

DNA binding [IDA]
RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA, IMP]