BAIT

WDR81

CAMRQ2, PPP1R166
WD repeat domain 81
Cell Cycle - Mitotic Spindle Assembly Project
GO Process (1)
GO Function (0)
GO Component (0)

Gene Ontology Biological Process

Homo sapiens
PREY

WDR91

HSPC049
WD repeat domain 91
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens

Co-localization

Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.

Publication

The BEACH-containing protein WDR81 coordinates p62 and LC3C to promote aggrephagy.

Liu X, Li Y, Wang X, Xing R, Liu K, Gan Q, Tang C, Gao Z, Jian Y, Luo S, Guo W, Yang C

Autophagy-dependent clearance of ubiquitinated and aggregated proteins is critical to protein quality control, but the underlying mechanisms are not well understood. Here, we report the essential role of the BEACH (beige and Chediak-Higashi) and WD40 repeat-containing protein WDR81 in eliminating ubiquitinated proteins through autophagy. WDR81 associates with ubiquitin (Ub)-positive protein foci, and its loss causes accumulation of Ub proteins and ... [more]

J. Cell Biol. May. 01, 2017; 216(5);1301-1320 [Pubmed: 28404643]

Throughput

  • Low Throughput

Curated By

  • BioGRID