SEC14
Gene Ontology Biological Process
- Golgi to plasma membrane protein transport [IMP]
- Golgi to vacuole transport [IGI, IMP]
- Golgi vesicle budding [IDA]
- ascospore formation [IMP]
- negative regulation of phosphatidylcholine biosynthetic process [IDA, IMP]
- negative regulation of phosphatidylglycerol biosynthetic process [IMP]
- phosphatidylinositol metabolic process [IGI, IMP]
- phospholipid transport [IDA, IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CSR1
Gene Ontology Biological Process
- Golgi to plasma membrane protein transport [IGI]
- Golgi to plasma membrane transport [IGI]
- negative regulation of fatty acid biosynthetic process [IDA, IGI, IMP]
- negative regulation of phosphatidylglycerol biosynthetic process [IGI]
- phosphatidylinositol metabolic process [IGI]
- phospholipid transport [IDA]
- positive regulation of phosphatidylcholine biosynthetic process [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Dosage Rescue
A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene.
Publication
A phosphatidylinositol transfer protein integrates phosphoinositide signaling with lipid droplet metabolism to regulate a developmental program of nutrient stress-induced membrane biogenesis.
Lipid droplet (LD) utilization is an important cellular activity that regulates energy balance and release of lipid second messengers. Because fatty acids exhibit both beneficial and toxic properties, their release from LDs must be controlled. Here we demonstrate that yeast Sfh3, an unusual Sec14-like phosphatidylinositol transfer protein, is an LD-associated protein that inhibits lipid mobilization from these particles. We further ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: vegetative growth (APO:0000106)
Additional Notes
- Figure 1
- sec14-1
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SEC14 CSR1 | Dosage Rescue Dosage Rescue A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene. | Low | - | BioGRID | 161695 | |
| SEC14 CSR1 | Dosage Rescue Dosage Rescue A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene. | High | - | BioGRID | 567358 | |
| SEC14 CSR1 | Dosage Rescue Dosage Rescue A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene. | Low | - | BioGRID | 259844 | |
| SEC14 CSR1 | Dosage Rescue Dosage Rescue A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene. | Low | - | BioGRID | 155380 | |
| SEC14 CSR1 | Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 448922 | |
| SEC14 CSR1 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | High | - | BioGRID | 258395 |
Curated By
- BioGRID