CDC7
Gene Ontology Biological Process
- DNA replication initiation [IMP]
- double-strand break repair via break-induced replication [IMP]
- negative regulation of exit from mitosis [IPI]
- peptidyl-serine phosphorylation [IDA]
- positive regulation of meiosis I [IGI]
- positive regulation of meiotic DNA double-strand break formation [IGI]
- premeiotic DNA replication [IMP]
- protein phosphorylation [IMP]
- regulation of chromatin silencing at telomere [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
GLC7
Gene Ontology Biological Process
- DNA damage checkpoint [IMP]
- DNA replication checkpoint [IGI, IMP]
- ascospore formation [IMP]
- cell budding [IMP]
- cellular ion homeostasis [IMP]
- chromosome segregation [IMP]
- dephosphorylation of RNA polymerase II C-terminal domain [IDA]
- glycogen metabolic process [IMP]
- histone dephosphorylation [IDA, IMP]
- meiotic nuclear division [IPI]
- mitotic spindle assembly checkpoint [IMP]
- positive regulation of protein dephosphorylation [IMP]
- protein dephosphorylation [IDA]
- protein localization to kinetochore [IMP]
- rRNA processing [IMP]
- regulation of carbohydrate metabolic process [IGI, IPI]
- regulation of cell cycle [IMP]
- regulation of cell shape during vegetative growth phase [IGI]
- regulation of mitotic cell cycle [IMP]
- replication fork processing [IMP]
- response to heat [IMP, IPI]
- termination of RNA polymerase II transcription, exosome-dependent [IPI]
- termination of RNA polymerase II transcription, poly(A)-coupled [IPI]
- transfer RNA gene-mediated silencing [IMP]
Gene Ontology Molecular Function
Dosage Growth Defect
A genetic interaction is inferred when over expression or increased dosage of one gene causes a growth defect in a strain that is mutated or deleted for another gene.
Publication
Rif1 controls DNA replication timing in yeast through the PP1 phosphatase Glc7.
The Rif1 protein, originally identified as a telomere-binding factor in yeast, has recently been implicated in DNA replication control from yeast to metazoans. Here, we show that budding yeast Rif1 protein inhibits activation of prereplication complexes (pre-RCs). This inhibitory function requires two N-terminal motifs, RVxF and SILK, associated with recruitment of PP1 phosphatase (Glc7). In G1 phase, we show both ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: vegetative growth (APO:0000106)
Additional Notes
- cdc7-4
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CDC7 GLC7 | Dosage Lethality Dosage Lethality A genetic interaction is inferred when over expression or increased dosage of one gene causes lethality in a strain that is mutated or deleted for another gene. | Low | - | BioGRID | 1277183 | |
| CDC7 GLC7 | Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 1277186 |
Curated By
- BioGRID