Publication

Activation-Dependent TRAF3 Exon 8 Alternative Splicing Is Controlled by CELF2 and hnRNP C Binding to an Upstream Intronic Element.

Schultz AS, Preussner M, Bunse M, Karni R, Heyd F

Cell-type-specific and inducible alternative splicing has a fundamental impact on regulating gene expression and cellular function in a variety of settings, including activation and differentiation. We have recently shown that activation-induced skipping of TRAF3 exon 8 activates noncanonical NF-κB signaling upon T cell stimulation, but the regulatory basis for this splicing event remains unknown. Here we identifycis- andtrans-regulatory elements rendering ... [more]

Throughput

• Low Throughput

Additional Notes

• protein(s) IPd from lysate with anti-CELF2 antibody interact with (i.e. likely are a) binding partner of RNA of TRAF3 exon8

Curated By

• BioGRID