BAIT
CD74
DHLAG, HLADG, II, Ia-GAMMA
CD74 molecule, major histocompatibility complex, class II invariant chain
GO Process (22)
GO Function (10)
GO Component (18)
Gene Ontology Biological Process
- T cell selection [NAS]
- antigen processing and presentation of endogenous antigen [NAS]
- antigen processing and presentation of exogenous peptide antigen via MHC class II [TAS]
- cell proliferation [IDA]
- immunoglobulin mediated immune response [ISS]
- intracellular protein transport [ISS]
- negative regulation of DNA damage response, signal transduction by p53 class mediator [IDA]
- negative regulation of apoptotic process [IDA]
- negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [IMP]
- negative regulation of peptide secretion [IDA]
- positive regulation of B cell proliferation [IMP]
- positive regulation of ERK1 and ERK2 cascade [IDA, IMP]
- positive regulation of chemokine (C-X-C motif) ligand 2 production [ISS]
- positive regulation of cytokine-mediated signaling pathway [IMP]
- positive regulation of fibroblast proliferation [IMP]
- positive regulation of macrophage cytokine production [ISS]
- positive regulation of neutrophil chemotaxis [ISS]
- positive regulation of peptidyl-tyrosine phosphorylation [IDA]
- prostaglandin biosynthetic process [IDA]
- protein complex assembly [ISS]
- regulation of macrophage activation [NAS]
- signal transduction [IDA]
Gene Ontology Molecular Function- MHC class II protein binding [ISS, NAS]
- MHC class II protein binding, via antigen binding groove [IDA]
- MHC class II protein complex binding [IDA]
- beta-amyloid binding [IPI]
- cytokine binding [IPI]
- cytokine receptor activity [IDA]
- identical protein binding [TAS]
- macrophage migration inhibitory factor binding [IPI]
- protein binding [IPI]
- protein binding involved in protein folding [IDA]
- MHC class II protein binding [ISS, NAS]
- MHC class II protein binding, via antigen binding groove [IDA]
- MHC class II protein complex binding [IDA]
- beta-amyloid binding [IPI]
- cytokine binding [IPI]
- cytokine receptor activity [IDA]
- identical protein binding [TAS]
- macrophage migration inhibitory factor binding [IPI]
- protein binding [IPI]
- protein binding involved in protein folding [IDA]
Gene Ontology Cellular Component
- ER to Golgi transport vesicle membrane [TAS]
- Golgi membrane [TAS]
- MHC class II protein complex [ISS]
- cell surface [IDA]
- clathrin-coated endocytic vesicle membrane [TAS]
- endocytic vesicle membrane [TAS]
- extracellular vesicular exosome [IDA]
- integral component of lumenal side of endoplasmic reticulum membrane [TAS]
- integral component of membrane [IDA]
- intracellular [TAS]
- lysosomal lumen [TAS]
- lysosomal membrane [TAS]
- macrophage migration inhibitory factor receptor complex [IDA]
- membrane [IDA]
- plasma membrane [TAS]
- trans-Golgi network membrane [TAS]
- transport vesicle membrane [TAS]
- vacuole [IDA]
Homo sapiens
PREY
CD44
CDW44, CSPG8, ECMR-III, HCELL, HUTCH-I, IN, LHR, MC56, MDU2, MDU3, MIC4, Pgp1, AL133330.1
CD44 molecule (Indian blood group)
GO Process (25)
GO Function (5)
GO Component (8)
Gene Ontology Biological Process
- blood coagulation [TAS]
- carbohydrate metabolic process [TAS]
- cartilage development [IEP]
- cell-matrix adhesion [NAS]
- cellular response to fibroblast growth factor stimulus [IDA]
- cytokine-mediated signaling pathway [TAS]
- extracellular matrix disassembly [TAS]
- extracellular matrix organization [TAS]
- glycosaminoglycan metabolic process [TAS]
- hyaluronan catabolic process [IDA, TAS]
- hyaluronan metabolic process [TAS]
- interferon-gamma-mediated signaling pathway [TAS]
- leukocyte migration [TAS]
- monocyte aggregation [IMP]
- negative regulation of DNA damage response, signal transduction by p53 class mediator [IDA]
- negative regulation of apoptotic process [IMP]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [IDA]
- positive regulation of ERK1 and ERK2 cascade [IDA]
- positive regulation of heterotypic cell-cell adhesion [IMP]
- positive regulation of monocyte aggregation [IMP]
- positive regulation of peptidyl-serine phosphorylation [IDA]
- positive regulation of peptidyl-tyrosine phosphorylation [IDA]
- single organismal cell-cell adhesion [NAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
FRET
An interaction is inferred when close proximity of interaction partners is detected by fluorescence resonance energy transfer between pairs of fluorophore-labeled molecules, such as occurs between CFP (donor) and YFP (acceptor) fusion proteins.
Publication
MIF allele-dependent regulation of the MIF coreceptor CD44 and role in rheumatoid arthritis.
Fibroblast-like synoviocytes mediate joint destruction in rheumatoid arthritis and exhibit sustained proinflammatory and invasive properties. CD44 is a polymorphic transmembrane protein with defined roles in matrix interaction and tumor invasion that is also a signaling coreceptor for macrophage migration inhibitory factor (MIF), which engages cell surface CD74. High-expression MIF alleles (rs5844572) are associated with rheumatoid joint erosion, but whether MIF ... [more]
Proc. Natl. Acad. Sci. U.S.A. Dec. 06, 2016; 113(49);E7917-E7926 [Pubmed: 27872288]
Throughput
- Low Throughput
Curated By
- BioGRID