A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Publication

Translation initiation in Saccharomyces cerevisiae mitochondria: functional interactions among mitochondrial ribosomal protein Rsm28p, initiation factor 2, methionyl-tRNA-formyltransferase and novel protein Rmd9p.

Williams EH, Butler CA, Bonnefoy N, Fox TD

Rsm28p is a dispensable component of the mitochondrial ribosomal small subunit in Saccharomyces cerevisiae that is not related to known proteins found in bacteria. It was identified as a dominant suppressor of certain mitochondrial mutations that reduced translation of the COX2 mRNA. To explore further the function of Rsm28p, we isolated mutations in other genes that caused a synthetic respiratory ... [more]

Genetics Mar. 01, 2007; 175(3);1117-26 [Pubmed: 17194786]

Throughput

Low Throughput

Ontology Terms

phenotype: respiratory metabolism (APO:0000102)

Additional Notes

synthetic respiratory defects

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
IFM1 RSM28	Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.	Costanzo M (2016)	High	-0.1894	BioGRID	2178674
IFM1 RSM28	Synthetic Rescue Synthetic Rescue A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene.	Williams EH (2007)	Low	-	BioGRID	238770

Curated By

BioGRID

Interaction Summary

RSM28

Gene Ontology Biological Process

Gene Ontology Molecular Function

structural constituent of ribosome [IDA]

Gene Ontology Cellular Component

IFM1