BAIT

IFM1

translation initiation factor 2, L000000854, YOL023W
Mitochondrial translation initiation factor 2
GO Process (3)
GO Function (3)
GO Component (1)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)
PREY

RSM28

mitochondrial 37S ribosomal protein RSM28, YDR494W
Mitochondrial ribosomal protein of the small subunit; genetic interactions suggest a possible role in promoting translation initiation
GO Process (2)
GO Function (1)
GO Component (2)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)

Synthetic Rescue

A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene.

Publication

Translation initiation in Saccharomyces cerevisiae mitochondria: functional interactions among mitochondrial ribosomal protein Rsm28p, initiation factor 2, methionyl-tRNA-formyltransferase and novel protein Rmd9p.

Williams EH, Butler CA, Bonnefoy N, Fox TD

Rsm28p is a dispensable component of the mitochondrial ribosomal small subunit in Saccharomyces cerevisiae that is not related to known proteins found in bacteria. It was identified as a dominant suppressor of certain mitochondrial mutations that reduced translation of the COX2 mRNA. To explore further the function of Rsm28p, we isolated mutations in other genes that caused a synthetic respiratory ... [more]

Genetics Mar. 01, 2007; 175(3);1117-26 [Pubmed: 17194786]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: respiratory metabolism (APO:0000102)

Additional Notes

  • dominant mutation RSM28-1 partially suppresses the ifm1 mutation

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
IFM1 RSM28
Negative Genetic
Negative Genetic

Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.

High-0.1894BioGRID
2178674
RSM28 IFM1
Phenotypic Enhancement
Phenotypic Enhancement

A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Low-BioGRID
238768

Curated By

  • BioGRID