BAIT

TCO89

YPL180W
Subunit of TORC1 (Tor1p or Tor2p-Kog1p-Lst8p-Tco89p); regulates global H3K56ac; TORC1 complex regulates growth in response to nutrient availability; cooperates with Ssd1p in the maintenance of cellular integrity; deletion strains are hypersensitive to rapamycin
Kinome Project (Sc)
Saccharomyces cerevisiae (S288c)
PREY

STU2

L000003019, YLR045C
Microtubule-associated protein (MAP) of the XMAP215/Dis1 family; regulates microtubule dynamics during spindle orientation and metaphase chromosome alignment; interacts with spindle pole body component Spc72p
GO Process (2)
GO Function (2)
GO Component (5)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)

Phenotypic Suppression

A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Publication

TORC1 signaling exerts spatial control over microtubule dynamics by promoting nuclear export of Stu2.

van der Vaart B, Fischboeck J, Mieck C, Pichler P, Mechtler K, Medema RH, Westermann S

The target of rapamycin complex 1 (TORC1) is a highly conserved multiprotein complex that functions in many cellular processes, including cell growth and cell cycle progression. In this study, we define a novel role for TORC1 as a critical regulator of nuclear microtubule (MT) dynamics in the budding yeast Saccharomyces cerevisiae This activity requires interactions between EB1 and CLIP-170 plus ... [more]

J. Cell Biol. Nov. 06, 2017; 216(11);3471-3484 [Pubmed: 28972103]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: cytoskeleton morphology (APO:0000054)

Additional Notes

  • Figure 4
  • stu2-2D

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
STU2 TCO89
Negative Genetic
Negative Genetic

Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.

High-0.1243BioGRID
397107

Curated By

  • BioGRID