BAIT

FIBP

FGFIBP, FIBP-1

fibroblast growth factor (acidic) intracellular binding protein

GO Process (2)

GO Function (1)

GO Component (5)

Gene Ontology Biological Process

fibroblast growth factor receptor signaling pathway [TAS]

platelet aggregation [IMP]

Gene Ontology Molecular Function

fibroblast growth factor binding [IPI]

Gene Ontology Cellular Component

extracellular vesicular exosome [IDA]

mitochondrion [TAS]

nucleoplasm [IDA]

CRISPR Database OMIM VEGA HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

PREY

MIF

GIF, GLIF, MMIF

macrophage migration inhibitory factor (glycosylation-inhibiting factor)

Arachidonic Acid Pathway Project

GO Process (21)

GO Function (7)

GO Component (6)

Gene Ontology Biological Process

carboxylic acid metabolic process [IDA]

cell proliferation [IDA]

cell surface receptor signaling pathway [IDA]

negative regulation of DNA damage response, signal transduction by p53 class mediator [IDA]

negative regulation of apoptotic process [IDA]

negative regulation of cell aging [IDA]

negative regulation of cell cycle arrest [IDA]

negative regulation of gene expression [IDA]

negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [IDA]

positive chemotaxis [IDA]

positive regulation of B cell proliferation [IDA]

positive regulation of ERK1 and ERK2 cascade [IDA]

positive regulation of cytokine secretion [IDA]

positive regulation of fibroblast proliferation [IDA]

positive regulation of peptidyl-serine phosphorylation [IDA]

positive regulation of peptidyl-tyrosine phosphorylation [IDA]

positive regulation of phosphorylation [IDA]

positive regulation of protein kinase A signaling [IDA]

prostaglandin biosynthetic process [IDA]

protein homotrimerization [IPI]

regulation of macrophage activation [NAS]

Gene Ontology Molecular Function

chemoattractant activity [IDA]
cytokine activity [IDA]
cytokine receptor binding [IPI]
dopachrome isomerase activity [IDA]
phenylpyruvate tautomerase activity [IDA]
protein binding [IPI]
receptor binding [IPI]

Gene Ontology Cellular Component

cell surface [IDA]

cytoplasm [IDA]

extracellular region [IDA]

extracellular vesicular exosome [IDA]

nucleoplasm [IDA]

CRISPR Database OMIM HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB HPRD

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Large-scale mapping of human protein-protein interactions by mass spectrometry.

Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D

Mapping protein-protein interactions is an invaluable tool for understanding protein function. Here, we report the first large-scale study of protein-protein interactions in human cells using a mass spectrometry-based approach. The study maps protein interactions for 338 bait proteins that were selected based on known or suspected disease and functional associations. Large-scale immunoprecipitation of Flag-tagged versions of these proteins followed by ... [more]

Mol. Syst. Biol. Mar. 14, 2007; 3(0);89 [Pubmed: 17353931]

Throughput

High Throughput

Ontology Terms

hek-293 cell (BTO:0000007)

Additional Notes

Exogenous expression of bait

Curated By

BioGRID