BAIT

BMPR2

BMPR-II, BMPR3, BMR2, BRK-3, POVD1, PPH1, T-ALK
bone morphogenetic protein receptor, type II (serine/threonine kinase)
GO Process (30)
GO Function (2)
GO Component (5)

Gene Ontology Molecular Function

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel electrophoresis and mass spectrometry.

Hassel S, Eichner A, Yakymovych M, Hellman U, Knaus P, Souchelnytskyi S

Bone morphogenetic proteins (BMP) are polypeptide growth factors that regulate cell differentiation and proliferation. BMPs bind to type I and type II serine/threonine kinase receptors to initiate intracellular signalling. BMPR-II is the type II receptor, its mutations lead to hereditary pulmonary hypertension, and knockout of Bmpr-II results in early embryonic lethality. To identify novel interacting proteins and explore signalling pathways ... [more]

Proteomics May. 01, 2004; 4(5);1346-58 [Pubmed: 15188402]

Throughput

  • High Throughput

Additional Notes

  • aa 501-1038 (tail)

Curated By

  • BioGRID