NCOA6
Gene Ontology Biological Process
- DNA recombination [NAS]
- DNA repair [NAS]
- DNA replication [NAS]
- DNA-templated transcription, initiation [IDA]
- brain development [ISS]
- cellular lipid metabolic process [TAS]
- cellular response to DNA damage stimulus [IDA]
- glucocorticoid receptor signaling pathway [NAS]
- heart development [ISS]
- intracellular estrogen receptor signaling pathway [NAS]
- myeloid cell differentiation [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [TAS]
- response to hormone [TAS]
- small molecule metabolic process [TAS]
- transcription initiation from RNA polymerase II promoter [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
NR3C1
Gene Ontology Biological Process
- cellular response to steroid hormone stimulus [IDA]
- gene expression [TAS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of transcription, DNA-templated [IDA]
- signal transduction [TAS]
- transcription from RNA polymerase II promoter [TAS]
- transcription initiation from RNA polymerase II promoter [TAS]
- transcription, DNA-templated [TAS]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- glucocorticoid receptor activity [TAS]
- glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity [IDA]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- steroid binding [IDA]
- steroid hormone binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- glucocorticoid receptor activity [TAS]
- glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity [IDA]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- steroid binding [IDA]
- steroid hormone binding [IDA]
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo.
Many transcription coactivators interact with nuclear receptors in a ligand- and C-terminal transactivation function (AF2)-dependent manner. We isolated a nuclear factor (designated ASC-2) with such properties by using the ligand-binding domain of retinoid X receptor as a bait in a yeast two-hybrid screening. ASC-2 also interacted with other nuclear receptors, including retinoic acid receptor, thyroid hormone receptor, estrogen receptor alpha, ... [more]
Throughput
- Low Throughput
Additional Notes
- ASC-2, either alone or in conjunction with CBP/p300 and SRC-1, stimulated ligand-dependent transactivation by wild type nuclear receptors but not mutant receptors lacking the AF2 domain
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| NR3C1 NCOA6 | Protein-peptide Protein-peptide An interaction is detected between a protein and a peptide derived from an interaction partner. This includes phage display experiments. | High | - | BioGRID | - | |
| NR3C1 NCOA6 | Proximity Label-MS Proximity Label-MS An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods. | High | - | BioGRID | - | |
| NR3C1 NCOA6 | Proximity Label-MS Proximity Label-MS An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods. | Low | - | BioGRID | 2327380 | |
| NCOA6 NR3C1 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - | |
| NCOA6 NR3C1 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID