BAIT
BMPR2
BMPR-II, BMPR3, BMR2, BRK-3, POVD1, PPH1, T-ALK
bone morphogenetic protein receptor, type II (serine/threonine kinase)
GO Process (30)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
- BMP signaling pathway [IDA, IMP, ISS, TAS]
- activin receptor signaling pathway [TAS]
- anterior/posterior pattern specification [ISS]
- artery development [ISS]
- blood vessel remodeling [ISS]
- cellular response to starvation [IEP]
- chondrocyte development [IMP]
- lung alveolus development [ISS]
- lymphangiogenesis [ISS]
- lymphatic endothelial cell differentiation [ISS]
- mesoderm formation [ISS]
- negative regulation of DNA biosynthetic process [IMP]
- negative regulation of cell growth [IDA]
- negative regulation of chondrocyte proliferation [IMP]
- negative regulation of systemic arterial blood pressure [IMP]
- negative regulation of vasoconstriction [ISS]
- positive regulation of BMP signaling pathway [IMP]
- positive regulation of bone mineralization [IMP]
- positive regulation of endothelial cell migration [IMP]
- positive regulation of endothelial cell proliferation [IMP]
- positive regulation of epithelial cell migration [IDA]
- positive regulation of osteoblast differentiation [IMP]
- positive regulation of pathway-restricted SMAD protein phosphorylation [IMP]
- regulation of cell proliferation [IMP]
- regulation of lung blood pressure [IMP, ISS]
- retina vasculature development in camera-type eye [ISS]
- transcription from RNA polymerase II promoter [IMP]
- transmembrane receptor protein serine/threonine kinase signaling pathway [IDA]
- vascular endothelial growth factor receptor signaling pathway [ISS]
- venous blood vessel development [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
TGFBR1
AAT5, ACVRLK4, ALK-5, ALK5, ESS1, LDS1, LDS1A, LDS2A, MSSE, SKR4, TGFR-1, tbetaR-I, RP11-96L7.1
transforming growth factor, beta receptor 1
GO Process (43)
GO Function (11)
GO Component (4)
Gene Ontology Biological Process
- activation of MAPKK activity [IDA]
- anterior/posterior pattern specification [ISS]
- artery morphogenesis [ISS]
- cell cycle arrest [TAS]
- cell motility [IMP]
- cellular response to transforming growth factor beta stimulus [IDA]
- collagen fibril organization [ISS]
- embryonic cranial skeleton morphogenesis [ISS]
- epithelial to mesenchymal transition [IDA]
- extracellular structure organization [TAS]
- germ cell migration [ISS]
- heart development [ISS]
- in utero embryonic development [ISS]
- kidney development [ISS]
- mesenchymal cell differentiation [TAS]
- negative regulation of chondrocyte differentiation [ISS]
- negative regulation of extrinsic apoptotic signaling pathway [IMP]
- negative regulation of transforming growth factor beta receptor signaling pathway [TAS]
- neuron fate commitment [ISS]
- palate development [ISS]
- parathyroid gland development [ISS]
- pathway-restricted SMAD protein phosphorylation [IDA]
- peptidyl-serine phosphorylation [IDA]
- peptidyl-threonine phosphorylation [IDA]
- pharyngeal system development [ISS]
- positive regulation of SMAD protein import into nucleus [IDA]
- positive regulation of apoptotic signaling pathway [IDA]
- positive regulation of cell growth [IDA]
- positive regulation of cell proliferation [IMP]
- positive regulation of cellular component movement [IMP]
- positive regulation of pathway-restricted SMAD protein phosphorylation [IDA]
- positive regulation of protein kinase B signaling [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- protein phosphorylation [IDA]
- regulation of protein ubiquitination [IDA]
- regulation of transcription, DNA-templated [IDA, IMP]
- response to cholesterol [IDA]
- signal transduction [IDA]
- skeletal system development [ISS]
- skeletal system morphogenesis [ISS]
- thymus development [ISS]
- transforming growth factor beta receptor signaling pathway [IC, IDA, IMP, TAS]
- wound healing [TAS]
Gene Ontology Molecular Function- ATP binding [IDA]
- I-SMAD binding [IPI]
- SMAD binding [IDA, IPI]
- growth factor binding [IPI]
- protein binding [IPI]
- protein kinase activity [IDA]
- protein serine/threonine kinase activity [IDA]
- transforming growth factor beta binding [IDA, IMP, IPI]
- transforming growth factor beta receptor activity, type I [IDA]
- transforming growth factor beta-activated receptor activity [IC, IDA, IMP]
- type II transforming growth factor beta receptor binding [IDA, IPI]
- ATP binding [IDA]
- I-SMAD binding [IPI]
- SMAD binding [IDA, IPI]
- growth factor binding [IPI]
- protein binding [IPI]
- protein kinase activity [IDA]
- protein serine/threonine kinase activity [IDA]
- transforming growth factor beta binding [IDA, IMP, IPI]
- transforming growth factor beta receptor activity, type I [IDA]
- transforming growth factor beta-activated receptor activity [IC, IDA, IMP]
- type II transforming growth factor beta receptor binding [IDA, IPI]
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPs.
Bone morphogenic proteins (BMPs) are universal regulators of animal development. We report the identification and cloning of the BMP type II receptor (BMPR-II), a missing component of this receptor system in vertebrates. BMPR-II is a transmembrane serine/threonine kinase that binds BMP-2 and BMP-7 in association with multiple type I receptors, including BMPR-IA/Brk1, BMPR-IB, and ActR-I, which is also an activin ... [more]
Mol. Cell. Biol. Jul. 01, 1995; 15(7);3479-86 [Pubmed: 7791754]
Throughput
- Low Throughput
Additional Notes
- cytoplasmic domain (aa 148-503) of TbetaR1
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| BMPR2 TGFBR1 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID