BAIT
MSN
HEL70
moesin
GO Process (7)
GO Function (6)
GO Component (12)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
TNFRSF1A
CD120a, FPF, MS5, TBP1, TNF-R, TNF-R-I, TNF-R55, TNFAR, TNFR1, TNFR1-d2, TNFR55, TNFR60, p55, p55-R, p60
tumor necrosis factor receptor superfamily, member 1A
GO Process (11)
GO Function (2)
GO Component (7)
Gene Ontology Biological Process
- apoptotic process [TAS]
- apoptotic signaling pathway [TAS]
- cellular response to mechanical stimulus [IEP]
- cytokine-mediated signaling pathway [ISS]
- extrinsic apoptotic signaling pathway via death domain receptors [TAS]
- inflammatory response [ISS]
- negative regulation of inflammatory response [IMP]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IEP]
- positive regulation of inflammatory response [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IMP, ISS]
- positive regulation of tyrosine phosphorylation of Stat1 protein [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Co-purification
An interaction is inferred from the identification of two or more protein subunits in a purified protein complex, as obtained by classical biochemical fractionation or affinity purification and one or more additional fractionation steps.
Publication
Cytoskeleton-mediated death receptor and ligand concentration in lipid rafts forms apoptosis-promoting clusters in cancer chemotherapy.
While investigating the mechanism of action of the novel antitumor drug Aplidin, we have discovered a potent and novel cell-killing mechanism that involves the formation of Fas/CD95-driven scaffolds in membrane raft clusters housing death receptors and apoptosis-related molecules. Fas, tumor necrosis factor-receptor 1, and tumor necrosis factor-related apoptosis-inducing ligand receptor 2/death receptor 5 were clustered into lipid rafts in leukemic ... [more]
J. Biol. Chem. Mar. 25, 2005; 280(12);11641-7 [Pubmed: 15659383]
Throughput
- Low Throughput
Additional Notes
- Fas, tumor necrosis factor-receptor 1, and tumor necrosis factor-related apoptosis-inducing ligand receptor 2/death receptor 5 were clustered into lipid rafts in leukemic Jurkat cells following Aplidin treatment;Fas ligand (FasL) as well as downstream sig
Curated By
- BioGRID