HSP90AA1
Gene Ontology Biological Process
- ATP catabolic process [IDA]
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- G2/M transition of mitotic cell cycle [TAS]
- axon guidance [TAS]
- chaperone-mediated protein complex assembly [IDA]
- innate immune response [TAS]
- mitochondrial transport [TAS]
- mitotic cell cycle [TAS]
- nitric oxide metabolic process [TAS]
- positive regulation of nitric oxide biosynthetic process [ISS]
- protein import into mitochondrial outer membrane [IDA]
- protein refolding [TAS]
- regulation of nitric-oxide synthase activity [TAS]
- response to unfolded protein [NAS]
- signal transduction [NAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
AHR
Gene Ontology Biological Process
- B cell differentiation [TAS]
- B cell homeostasis [IMP, TAS]
- B-1 B cell homeostasis [TAS]
- T cell homeostasis [IMP]
- blood circulation [IMP]
- blood vessel development [IMP]
- blood vessel morphogenesis [IMP]
- blood vessel remodeling [IMP]
- camera-type eye development [IMP]
- cardiac left ventricle morphogenesis [IMP]
- cell morphogenesis [IMP]
- cellular response to cAMP [IDA]
- circadian regulation of gene expression [IDA]
- circumferential growth involved in left ventricle morphogenesis [IMP]
- common bile duct development [IMP]
- embryonic hemopoiesis [IMP]
- gland development [IMP]
- glomerulus morphogenesis [IMP]
- immune system process [IMP]
- intracellular receptor signaling pathway [IDA, ISO]
- kidney morphogenesis [IMP]
- liver development [IMP]
- lymphocyte homeostasis [IMP, TAS]
- negative regulation of necrotic cell death [IMP]
- negative regulation of systemic arterial blood pressure [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- negative regulation of vasoconstriction [IMP]
- ovarian follicle development [ISO]
- patterning of blood vessels [IMP]
- positive regulation of RNA polymerase II transcriptional preinitiation complex assembly [IDA]
- positive regulation of cell size [IMP]
- positive regulation of growth [IMP]
- positive regulation of transcription, DNA-templated [IDA]
- post-embryonic hemopoiesis [IMP]
- prostate gland development [IMP]
- regulation of B cell proliferation [ISO]
- regulation of blood pressure [TAS]
- regulation of blood vessel size [IMP]
- regulation of gene expression [ISO]
- regulation of heart growth [TAS]
- regulation of transcription from RNA polymerase II promoter [ISO]
- regulation of transcription, DNA-templated [IDA, ISO, TAS]
- reproductive structure development [IMP]
- response to organic cyclic compound [ISO]
- response to stress [IDA]
- response to toxic substance [IDA, ISO]
- response to xenobiotic stimulus [IDA, ISO]
- smooth muscle tissue development [IMP]
- spleen development [IMP]
- transcription from RNA polymerase II promoter [IDA, ISO]
- venous blood vessel development [IMP]
- xenobiotic metabolic process [TAS]
Gene Ontology Molecular Function- DNA binding [IDA, ISO]
- E-box binding [IDA]
- Hsp90 protein binding [ISO, TAS]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- aryl hydrocarbon receptor activity [ISO]
- enhancer binding [ISO]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA, ISO]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA, ISO, TAS]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [ISO]
- DNA binding [IDA, ISO]
- E-box binding [IDA]
- Hsp90 protein binding [ISO, TAS]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- aryl hydrocarbon receptor activity [ISO]
- enhancer binding [ISO]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA, ISO]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA, ISO, TAS]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [ISO]
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
A cellular factor stimulates ligand-dependent release of hsp90 from the basic helix-loop-helix dioxin receptor.
In response to dioxin, the nuclear basic helix-loop-helix (bHLH) dioxin receptor forms a complex with the bHLH partner factor Arnt that regulates target gene transcription by binding to dioxin-responsive sequence motifs. Previously, we have demonstrated that the latent form of dioxin receptor present in extracts from untreated cells is stably associated with molecular chaperone protein hsp90, and Arnt is not ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID