BAIT
MAPKAPK2
MAPKAP-K2, MK-2, MK2
mitogen-activated protein kinase-activated protein kinase 2
GO Process (38)
GO Function (4)
GO Component (6)
Gene Ontology Biological Process
- 3'-UTR-mediated mRNA stabilization [IDA]
- G2 DNA damage checkpoint [IMP]
- MAPK cascade [TAS]
- MyD88-dependent toll-like receptor signaling pathway [TAS]
- MyD88-independent toll-like receptor signaling pathway [TAS]
- RNA metabolic process [TAS]
- Ras protein signal transduction [TAS]
- TRIF-dependent toll-like receptor signaling pathway [TAS]
- activation of MAPK activity [TAS]
- arachidonic acid metabolic process [TAS]
- cellular response to DNA damage stimulus [IMP]
- cellular response to vascular endothelial growth factor stimulus [IMP]
- gene expression [TAS]
- inflammatory response [ISS]
- innate immune response [TAS]
- leukotriene metabolic process [TAS]
- mRNA metabolic process [TAS]
- macropinocytosis [ISS]
- neurotrophin TRK receptor signaling pathway [TAS]
- peptidyl-serine phosphorylation [IDA]
- protein phosphorylation [TAS]
- regulation of interleukin-6 production [ISS]
- regulation of tumor necrosis factor production [IDA]
- response to cytokine [IDA]
- response to lipopolysaccharide [ISS]
- response to stress [IDA]
- small molecule metabolic process [TAS]
- stress-activated MAPK cascade [TAS]
- toll-like receptor 10 signaling pathway [TAS]
- toll-like receptor 2 signaling pathway [TAS]
- toll-like receptor 3 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor 5 signaling pathway [TAS]
- toll-like receptor 9 signaling pathway [TAS]
- toll-like receptor TLR1:TLR2 signaling pathway [TAS]
- toll-like receptor TLR6:TLR2 signaling pathway [TAS]
- toll-like receptor signaling pathway [ISS, TAS]
- vascular endothelial growth factor receptor signaling pathway [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
TSC2
Rc
tuberous sclerosis 2
GO Process (34)
GO Function (7)
GO Component (18)
Gene Ontology Biological Process
- acute-phase response [IMP]
- cell projection organization [IGI, IMP]
- cellular response to insulin stimulus [ISO]
- establishment of protein localization [IMP]
- glucose import [ISO]
- heart development [ISO]
- insulin-like growth factor receptor signaling pathway [ISO]
- negative regulation of MAP kinase activity [IMP]
- negative regulation of TOR signaling [IDA, ISO]
- negative regulation of Wnt signaling pathway [IDA]
- negative regulation of cell proliferation [IMP, ISO]
- negative regulation of cell size [IMP]
- negative regulation of epithelial cell proliferation [IDA]
- negative regulation of insulin receptor signaling pathway [IBA]
- negative regulation of phosphatidylinositol 3-kinase signaling [ISO]
- negative regulation of protein kinase B signaling [IBA, ISO]
- negative regulation of protein kinase activity [ISO]
- neural tube closure [ISO]
- phosphatidylinositol 3-kinase signaling [ISO]
- positive chemotaxis [ISO]
- positive regulation of Rab GTPase activity [TAS]
- positive regulation of Ras GTPase activity [IBA]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- protein heterooligomerization [IDA, IMP]
- protein homooligomerization [IDA, IMP]
- protein import into nucleus [ISO]
- protein kinase B signaling [ISO]
- protein localization [ISO]
- protein transport into plasma membrane raft [ISO]
- regulation of cell cycle [IMP]
- regulation of endocytosis [ISO]
- regulation of insulin receptor signaling pathway [ISO]
- response to hypoxia [ISO]
- signal transduction [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- TSC1-TSC2 complex [IBA, ISO]
- caveola [IDA]
- cell [ISO]
- cytoplasm [ISO]
- cytoskeleton [IDA]
- cytosol [IDA, ISO]
- dendrite [IDA]
- growth cone [IDA]
- intracellular [ISO]
- intracellular membrane-bounded organelle [IDA]
- membrane [ISO]
- membrane raft [IDA]
- neuron projection [IDA]
- neuronal cell body [IDA]
- nucleus [ISO]
- perinuclear region of cytoplasm [IDA, ISO]
- protein complex [IDA]
Rattus norvegicus
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3.
Tuberous sclerosis complex (TSC) is a genetic disease caused by mutations in either TSC1 or TSC2 tumor suppressor genes. TSC1 and TSC2 (also known as hamartin and tuberin, respectively) form a functional complex and negatively regulate cell growth by inhibiting protein synthesis. 14-3-3 binds to TSC2 and may inhibit TSC2 function. We have reported previously that phosphorylation of serine 1210 ... [more]
J. Biol. Chem. Apr. 18, 2003; 278(16);13663-71 [Pubmed: 12582162]
Throughput
- Low Throughput
Curated By
- BioGRID