DRD3
Gene Ontology Biological Process
- G-protein coupled receptor internalization [IDA]
- G-protein coupled receptor signaling pathway [IDA]
- acid secretion [ISS]
- adenylate cyclase-activating dopamine receptor signaling pathway [IDA]
- adenylate cyclase-inhibiting dopamine receptor signaling pathway [IDA]
- arachidonic acid secretion [IDA]
- behavioral response to cocaine [IEP, ISS]
- cellular calcium ion homeostasis [IDA]
- circadian regulation of gene expression [ISS]
- dopamine metabolic process [IC]
- learning [NAS]
- learning or memory [NAS]
- locomotory behavior [ISS]
- musculoskeletal movement, spinal reflex action [ISS]
- negative regulation of adenylate cyclase activity [IDA]
- negative regulation of blood pressure [ISS]
- negative regulation of oligodendrocyte differentiation [ISS]
- negative regulation of protein kinase B signaling [ISS]
- negative regulation of protein secretion [IDA]
- positive regulation of cytokinesis [IMP]
- positive regulation of dopamine receptor signaling pathway [ISS]
- positive regulation of mitosis [ISS]
- prepulse inhibition [IMP]
- regulation of cAMP metabolic process [IDA]
- regulation of dopamine secretion [ISS]
- regulation of dopamine uptake involved in synaptic transmission [IC]
- response to cocaine [IEP]
- response to drug [ISS]
- response to ethanol [ISS]
- response to histamine [IDA]
- response to morphine [ISS]
- social behavior [NAS]
- visual learning [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PRKCB
Gene Ontology Biological Process
- B cell activation [ISS]
- B cell receptor signaling pathway [ISS]
- blood coagulation [TAS]
- histone H3-T6 phosphorylation [IDA]
- lipoprotein transport [TAS]
- negative regulation of glucose transport [ISS]
- negative regulation of insulin receptor signaling pathway [ISS]
- platelet activation [TAS]
- positive regulation of B cell receptor signaling pathway [ISS]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [ISS]
- positive regulation of NF-kappaB transcription factor activity [ISS]
- positive regulation of angiogenesis [ISS]
- positive regulation of vascular endothelial growth factor receptor signaling pathway [ISS]
- protein phosphorylation [TAS]
- regulation of transcription from RNA polymerase II promoter [IMP]
- signal transduction [NAS]
- synaptic transmission [TAS]
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
β-Arrestin2 directly or through GRK2 inhibits PKCβII activation in a ubiquitination-dependent manner.
The GRK/β-arrestin and PKC/PKA mediate the homologous and heterologous regulation of G protein-coupled receptors (GPCRs), respectively. Interaction between the two pathways is one of the most important issues in understanding the regulation of GPCRs. The present study investigated the regulatory effect of GRK2 and β-arrestins on PKC activation. The roles of GRK2 and β-arrestins in the functional regulation of PKC ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID