IPL1
Gene Ontology Biological Process
- attachment of spindle microtubules to kinetochore [IMP]
- chromosome segregation [IMP]
- homologous chromosome segregation [IMP]
- meiotic sister chromatid segregation [IMP]
- mitotic DNA integrity checkpoint [IGI]
- mitotic spindle disassembly [IMP]
- negative regulation of protein import into nucleus during spindle assembly checkpoint [IMP]
- positive regulation of spindle checkpoint [IMP]
- protein phosphorylation [IDA, IMP]
- regulation of cytokinesis [IMP]
- regulation of spindle assembly involved in mitosis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
GLC7
Gene Ontology Biological Process
- DNA damage checkpoint [IMP]
- DNA replication checkpoint [IGI, IMP]
- ascospore formation [IMP]
- cell budding [IMP]
- cellular ion homeostasis [IMP]
- chromosome segregation [IMP]
- dephosphorylation of RNA polymerase II C-terminal domain [IDA]
- glycogen metabolic process [IMP]
- histone dephosphorylation [IDA, IMP]
- meiotic nuclear division [IPI]
- mitotic spindle assembly checkpoint [IMP]
- positive regulation of protein dephosphorylation [IMP]
- protein dephosphorylation [IDA]
- protein localization to kinetochore [IMP]
- rRNA processing [IMP]
- regulation of carbohydrate metabolic process [IGI, IPI]
- regulation of cell cycle [IMP]
- regulation of cell shape during vegetative growth phase [IGI]
- regulation of mitotic cell cycle [IMP]
- replication fork processing [IMP]
- response to heat [IMP, IPI]
- termination of RNA polymerase II transcription, exosome-dependent [IPI]
- termination of RNA polymerase II transcription, poly(A)-coupled [IPI]
- transfer RNA gene-mediated silencing [IMP]
Gene Ontology Molecular Function
Phenotypic Suppression
A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
New ubiquitin-dependent mechanisms regulating the Aurora B-Protein Phosphatase 1 balance in Saccharomyces cerevisiae.
Protein ubiquitylation regulates many cellular processes, including cell division. We report here a novel mutation altering the S. cerevisiae E1 ubiquitin activating enzyme (uba1-W928R) that suppresses the temperature sensitivity and chromosome loss phenotype of a well-characterized Aurora B mutant (ip1-2). The uba1-W928R mutation increases Histone H3-S10 phosphorylation in the ipl1-2 strain, indicating that uba1-W928R acts by increasing Ipl1 activity and/or ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: protein/peptide modification (APO:0000131)
Additional Notes
- deletion of uba1 or glc7 suppresses the loss of Histone 3 acetylation seen in an Ipl1 mutant
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| IPL1 GLC7 | Dosage Lethality Dosage Lethality A genetic interaction is inferred when over expression or increased dosage of one gene causes lethality in a strain that is mutated or deleted for another gene. | Low | - | BioGRID | 153842 | |
| IPL1 GLC7 | Synthetic Rescue Synthetic Rescue A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene. | Low | - | BioGRID | 268536 | |
| IPL1 GLC7 | Synthetic Rescue Synthetic Rescue A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene. | Low | - | BioGRID | 159466 | |
| IPL1 GLC7 | Synthetic Rescue Synthetic Rescue A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene. | Low | - | BioGRID | 196273 | |
| IPL1 GLC7 | Synthetic Rescue Synthetic Rescue A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene. | Low | - | BioGRID | 797091 | |
| IPL1 GLC7 | Synthetic Rescue Synthetic Rescue A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene. | High | - | BioGRID | 544257 |
Curated By
- BioGRID