BAIT
BMPR1A
10q23del, ACVRLK3, ALK3, CD292, SKR5
bone morphogenetic protein receptor, type IA
GO Process (9)
GO Function (6)
GO Component (2)
Gene Ontology Biological Process
- BMP signaling pathway [IDA, TAS]
- endocardial cushion formation [ISS]
- immune response [IMP]
- positive regulation of SMAD protein import into nucleus [IDA]
- positive regulation of bone mineralization [IMP]
- positive regulation of osteoblast differentiation [IMP]
- positive regulation of pathway-restricted SMAD protein phosphorylation [IDA]
- protein phosphorylation [IDA]
- transforming growth factor beta receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- caveola [IMP]
- plasma membrane [IDA, TAS]
Homo sapiens
PREY
FKBP1B
FKBP12.6, FKBP1L, OTK4, PKBP1L, PPIase
FK506 binding protein 1B, 12.6 kDa
GO Process (18)
GO Function (7)
GO Component (6)
Gene Ontology Biological Process
- 'de novo' protein folding [TAS]
- calcium ion transmembrane transport [TAS]
- calcium-mediated signaling using intracellular calcium source [TAS]
- cell communication by electrical coupling involved in cardiac conduction [TAS]
- chaperone-mediated protein folding [IBA]
- cytosolic calcium ion homeostasis [IDA, IGI]
- negative regulation of heart rate [ISS]
- negative regulation of protein phosphatase type 2B activity [IDA]
- negative regulation of release of sequestered calcium ion into cytosol [IDA]
- negative regulation of ryanodine-sensitive calcium-release channel activity [IDA]
- positive regulation of sequestering of calcium ion [IDA]
- protein maturation by protein folding [TAS]
- protein peptidyl-prolyl isomerization [IDA]
- protein refolding [TAS]
- regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [IBA, ISS]
- regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [IDA]
- regulation of ryanodine-sensitive calcium-release channel activity [IDA, IMP]
- response to redox state [IDA]
Gene Ontology Molecular Function
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Interaction of the BMPR-IA tumor suppressor with a developmentally relevant splicing factor.
Inactivation of bone morphogenetic protein signaling via mutation of the BMPR-IA TGF-beta superfamily type I receptor causes familial juvenile polyposis, an inherited gastrointestinal cancer predisposition syndrome. In an effort to provide new insight into the mechanism(s) of BMP-mediated tumor suppression, we employed a yeast two-hybrid screen to identify novel proteins that interact with the intracellular domain of BMPR-IA. 30/31 interacting ... [more]
Biochem. Biophys. Res. Commun. Oct. 08, 2004; 323(1);91-7 [Pubmed: 15351706]
Throughput
- Low Throughput
Curated By
- BioGRID