BCR
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PIK3CG
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IDA]
- T cell activation [TAS]
- T cell chemotaxis [TAS]
- T cell proliferation [TAS]
- adaptive immune response [TAS]
- blood coagulation [TAS]
- cytokine production [TAS]
- dendritic cell chemotaxis [TAS]
- inflammatory response [TAS]
- innate immune response [TAS]
- mast cell degranulation [TAS]
- natural killer cell chemotaxis [TAS]
- negative regulation of cardiac muscle contraction [TAS]
- neutrophil chemotaxis [TAS]
- neutrophil extravasation [TAS]
- phosphatidylinositol 3-kinase signaling [IDA, TAS]
- phosphatidylinositol biosynthetic process [TAS]
- phospholipid metabolic process [TAS]
- platelet activation [TAS]
- platelet aggregation [TAS]
- positive regulation of MAP kinase activity [IDA]
- positive regulation of protein kinase B signaling [IDA]
- regulation of cell adhesion mediated by integrin [TAS]
- respiratory burst involved in defense response [TAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Phosphatidylinositol-3 kinase activity is regulated by BCR/ABL and is required for the growth of Philadelphia chromosome-positive cells.
The BCR/ABL oncogenic tyrosine kinase is responsible for initiating and maintaining the leukemic phenotype of Philadelphia chromosome (Ph1)-positive cells. Phosphatidylinositol-3 (PI-3) kinase is known to interact with and be activated by receptor and nonreceptor tyrosine kinases. We investigated whether PI-3 kinase associates with and/or is regulated by BCR/ABL, whether this interaction is functionally significant for Ph1 cell proliferation, and, if ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| BCR PIK3CG | Co-localization Co-localization Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments. | High | - | BioGRID | 1504550 |
Curated By
- BioGRID