BAIT
ARNT
D3Ertd557e, Drnt, ESTM42, Hif1b, W08714, bHLHe2, mKIAA4051
aryl hydrocarbon receptor nuclear translocator
GO Process (13)
GO Function (12)
GO Component (4)
Gene Ontology Biological Process
- cell differentiation [IMP]
- embryonic placenta development [IMP]
- intracellular receptor signaling pathway [IMP]
- positive regulation of hormone biosynthetic process [ISO]
- positive regulation of protein sumoylation [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IGI]
- positive regulation of transcription, DNA-templated [IDA, ISO]
- positive regulation vascular endothelial growth factor production [ISO]
- regulation of nucleic acid-templated transcription [IPI]
- regulation of transcription from RNA polymerase II promoter in response to oxidative stress [ISO]
- regulation of transcription, DNA-templated [TAS]
- response to hypoxia [IDA, ISO]
- response to toxic substance [TAS]
Gene Ontology Molecular Function- DNA binding [IGI]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [ISO]
- aryl hydrocarbon receptor activity [IMP]
- aryl hydrocarbon receptor binding [ISO]
- enhancer binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IPI, ISO]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [TAS]
- transcription coactivator activity [IDA]
- transcription factor binding [ISO]
- transcription factor binding transcription factor activity [IPI]
- DNA binding [IGI]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [ISO]
- aryl hydrocarbon receptor activity [IMP]
- aryl hydrocarbon receptor binding [ISO]
- enhancer binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IPI, ISO]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [TAS]
- transcription coactivator activity [IDA]
- transcription factor binding [ISO]
- transcription factor binding transcription factor activity [IPI]
Mus musculus
PREY
HIF1A
HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
GO Process (34)
GO Function (13)
GO Component (7)
Gene Ontology Biological Process
- Notch signaling pathway [TAS]
- axon transport of mitochondrion [IMP]
- cellular response to hypoxia [IDA, IEP, TAS]
- cellular response to interleukin-1 [IEP]
- collagen metabolic process [ISS]
- connective tissue replacement involved in inflammatory response wound healing [ISS]
- elastin metabolic process [ISS]
- epithelial to mesenchymal transition [ISS]
- mRNA transcription from RNA polymerase II promoter [IC]
- negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [IDA]
- oxygen homeostasis [IDA]
- positive regulation of angiogenesis [IC]
- positive regulation of chemokine production [TAS]
- positive regulation of chemokine-mediated signaling pathway [IC]
- positive regulation of endothelial cell proliferation [IC]
- positive regulation of epithelial cell migration [ISS]
- positive regulation of erythrocyte differentiation [IC]
- positive regulation of glycolytic process [IC]
- positive regulation of hormone biosynthetic process [IDA]
- positive regulation of nitric-oxide synthase activity [TAS]
- positive regulation of receptor biosynthetic process [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI]
- positive regulation of transcription from RNA polymerase II promoter in response to hypoxia [IDA, IMP]
- positive regulation of transcription, DNA-templated [IDA, IMP]
- positive regulation of vascular endothelial growth factor receptor signaling pathway [IC]
- positive regulation vascular endothelial growth factor production [IDA, IMP]
- regulation of gene expression [IDA]
- regulation of transcription from RNA polymerase II promoter in response to hypoxia [TAS]
- regulation of transcription from RNA polymerase II promoter in response to oxidative stress [IDA]
- regulation of transcription, DNA-templated [IDA]
- regulation of transforming growth factor beta2 production [IMP]
- response to hypoxia [IDA, IMP]
- signal transduction [IMP]
- vascular endothelial growth factor production [IDA]
Gene Ontology Molecular Function- Hsp90 protein binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- enzyme binding [IPI]
- histone acetyltransferase binding [IPI]
- nuclear hormone receptor binding [IPI]
- protein binding [IPI]
- protein heterodimerization activity [IPI, TAS]
- protein kinase binding [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA, TAS]
- transcription factor binding [IPI]
- transcription factor binding transcription factor activity [IDA]
- ubiquitin protein ligase binding [IPI]
- Hsp90 protein binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- enzyme binding [IPI]
- histone acetyltransferase binding [IPI]
- nuclear hormone receptor binding [IPI]
- protein binding [IPI]
- protein heterodimerization activity [IPI, TAS]
- protein kinase binding [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA, TAS]
- transcription factor binding [IPI]
- transcription factor binding transcription factor activity [IDA]
- ubiquitin protein ligase binding [IPI]
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Functional interference between hypoxia and dioxin signal transduction pathways: competition for recruitment of the Arnt transcription factor.
Hypoxia-inducible factor 1 alpha (HIF-1 alpha) and the intracellular dioxin receptor mediate hypoxia and dioxin signalling, respectively. Both proteins are conditionally regulated basic helix-loop-helix (bHLH) transcription factors that, in addition to the bHLH motif, share a Per-Arnt-Sim (PAS) region of homology and form heterodimeric complexes with the common bHLH/PAS partner factor Arnt. Here we demonstrate that HIF-1 alpha required Arnt ... [more]
Mol. Cell. Biol. Oct. 01, 1996; 16(10);5221-31 [Pubmed: 8816435]
Throughput
- Low Throughput
Additional Notes
- Bait species unknown.
Curated By
- BioGRID