SNF11
Gene Ontology Biological Process
Gene Ontology Molecular Function
SWI1
Gene Ontology Biological Process
- ATP-dependent chromatin remodeling [IDA]
- DNA-dependent DNA replication [IMP]
- carbon catabolite activation of transcription from RNA polymerase II promoter [IGI]
- cellular alcohol catabolic process [IMP]
- positive regulation of mating type switching [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation [IMP]
- sucrose catabolic process [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- SWI/SNF complex [IDA, IMP]
- nucleus [IDA]
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Composition and Function of Mutant Swi/Snf Complexes.
The 12-subunit Swi/Snf chromatin remodeling complex is conserved from yeast to humans. It functions to alter nucleosome positions by either sliding nucleosomes on DNA or evicting histones. Interestingly, 20% of all human cancers carry mutations in subunits of the Swi/Snf complex. Many of these mutations cause protein instability and loss, resulting in partial Swi/Snf complexes. Although several studies have shown ... [more]
Throughput
- Low Throughput
Additional Notes
- MudPIT
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SNF11 SWI1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| SWI1 SNF11 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.3003 | BioGRID | 2020319 |
Curated By
- BioGRID