BAIT
PEA15
HMAT1, HUMMAT1H, MAT1, MAT1H, PEA-15, PED, RP11-536C5.8
phosphoprotein enriched in astrocytes 15
GO Process (3)
GO Function (1)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SNRPG
SMG, Sm-G
small nuclear ribonucleoprotein polypeptide G
GO Process (11)
GO Function (2)
GO Component (11)
Gene Ontology Biological Process
- RNA metabolic process [TAS]
- RNA splicing [TAS]
- gene expression [TAS]
- histone mRNA metabolic process [TAS]
- mRNA 3'-end processing [TAS]
- mRNA splicing, via spliceosome [IC, TAS]
- ncRNA metabolic process [TAS]
- spliceosomal complex assembly [NAS]
- spliceosomal snRNP assembly [IDA, TAS]
- termination of RNA polymerase II transcription [TAS]
- transcription from RNA polymerase II promoter [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
PEA15 regulates the DNA damage-induced cell cycle checkpoint and oncogene-directed transformation.
Regulation of the DNA damage response and cell cycle progression is critical for maintaining genome integrity. Here, we report that in response to DNA damage, COPS5 deubiquitinates and stabilizes PEA15 in an ATM kinase-dependent manner. PEA15 expression oscillates throughout the cell cycle, and the loss of PEA15 accelerates cell cycle progression by activating CDK6 expression via the c-JUN transcription factor. ... [more]
Mol. Cell. Biol. Jun. 01, 2014; 34(12);2264-82 [Pubmed: 24710276]
Throughput
- High Throughput
Curated By
- BioGRID