BAIT

KEAP1

INrf2, KLHL19
kelch-like ECH-associated protein 1
Cell Cycle - Mitotic Spindle Assembly Project
Synthetic Protein Interaction Project
UPS Project
Homo sapiens
PREY

EEF2

EEF-2, EF-2, EF2, SCA26
eukaryotic translation elongation factor 2
Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

NRF2 Induction Supporting Breast Cancer Cell Survival Is Enabled by Oxidative Stress-Induced DPP3-KEAP1 Interaction.

Lu K, Alcivar AL, Ma J, Foo TK, Zywea S, Mahdi A, Huo Y, Kensler TW, Gatza ML, Xia B

NRF2 is a transcription factor serving as a master regulator of the expression of many genes involved in cellular responses to oxidative and other stresses. In the absence of stress, NRF2 is constantly synthesized but maintained at low levels as it is targeted by KEAP1 for ubiquitination and proteasome-mediated degradation. NRF2 binds KEAP1 mainly through a conserved "ETGE" motif that ... [more]

Cancer Res. Dec. 01, 2016; 77(11);2881-2892 [Pubmed: 28416489]

Throughput

  • High Throughput

Curated By

  • BioGRID