BAIT
MAPK1
ERK, ERK-2, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk, p42-MAPK
mitogen-activated protein kinase 1
GO Process (46)
GO Function (4)
GO Component (14)
Gene Ontology Biological Process
- ERBB signaling pathway [IDA]
- ERK1 and ERK2 cascade [IDA, TAS]
- Fc-epsilon receptor signaling pathway [TAS]
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- JAK-STAT cascade involved in growth hormone signaling pathway [TAS]
- MAPK cascade [TAS]
- MyD88-dependent toll-like receptor signaling pathway [TAS]
- MyD88-independent toll-like receptor signaling pathway [TAS]
- Ras protein signal transduction [TAS]
- TRIF-dependent toll-like receptor signaling pathway [TAS]
- activation of MAPK activity [TAS]
- activation of MAPKK activity [TAS]
- axon guidance [TAS]
- blood coagulation [TAS]
- caveolin-mediated endocytosis [TAS]
- chemotaxis [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- insulin receptor signaling pathway [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- peptidyl-serine phosphorylation [IDA]
- peptidyl-threonine phosphorylation [ISS]
- platelet activation [TAS]
- positive regulation of peptidyl-threonine phosphorylation [IDA]
- regulation of Golgi inheritance [TAS]
- regulation of cytoskeleton organization [TAS]
- regulation of early endosome to late endosome transport [TAS]
- regulation of protein stability [ISS]
- regulation of sequence-specific DNA binding transcription factor activity [TAS]
- regulation of stress-activated MAPK cascade [TAS]
- response to epidermal growth factor [IDA]
- response to stress [TAS]
- signal transduction [TAS]
- small GTPase mediated signal transduction [TAS]
- stress-activated MAPK cascade [TAS]
- synaptic transmission [TAS]
- toll-like receptor 10 signaling pathway [TAS]
- toll-like receptor 2 signaling pathway [TAS]
- toll-like receptor 3 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor 5 signaling pathway [TAS]
- toll-like receptor 9 signaling pathway [TAS]
- toll-like receptor TLR1:TLR2 signaling pathway [TAS]
- toll-like receptor TLR6:TLR2 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
KLF4
EZF, Gklf, Zie, RP23-322L22.2
Kruppel-like factor 4 (gut)
GO Process (39)
GO Function (16)
GO Component (7)
Gene Ontology Biological Process
- canonical Wnt signaling pathway [IMP]
- cell differentiation [IMP]
- cellular response to growth factor stimulus [ISO]
- cellular response to laminar fluid shear stress [ISO]
- epidermal cell differentiation [IMP]
- epidermis morphogenesis [IMP]
- fat cell differentiation [IMP]
- negative regulation of ERK1 and ERK2 cascade [ISO]
- negative regulation of NF-kappaB transcription factor activity [ISO]
- negative regulation of cell migration involved in sprouting angiogenesis [ISO]
- negative regulation of cell proliferation [IDA]
- negative regulation of chemokine (C-X-C motif) ligand 2 production [ISO]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- negative regulation of heterotypic cell-cell adhesion [ISO]
- negative regulation of interleukin-8 biosynthetic process [ISO]
- negative regulation of muscle hyperplasia [ISO]
- negative regulation of phosphatidylinositol 3-kinase signaling [ISO]
- negative regulation of protein kinase B signaling [ISO]
- negative regulation of response to cytokine stimulus [ISO]
- negative regulation of smooth muscle cell proliferation [ISO]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- negative regulation of transcription, DNA-templated [ISO, ISS, NAS]
- positive regulation of cellular protein metabolic process [ISO]
- positive regulation of hemoglobin biosynthetic process [ISO]
- positive regulation of nitric oxide biosynthetic process [ISO]
- positive regulation of protein metabolic process [ISO]
- positive regulation of telomerase activity [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP, ISO]
- positive regulation of transcription, DNA-templated [IDA]
- post-embryonic camera-type eye development [IMP]
- post-embryonic hemopoiesis [ISO]
- regulation of cell differentiation [IDA]
- regulation of cell proliferation [IGI]
- regulation of phosphatidylinositol 3-kinase activity [ISO]
- regulation of transcription from RNA polymerase II promoter [IDA]
- response to organic substance [IDA]
- response to retinoic acid [IDA]
- stem cell maintenance [IDA]
- transcription from RNA polymerase II promoter [IDA, ISO]
Gene Ontology Molecular Function- DNA binding [ISS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA, ISO]
- RNA polymerase II transcription factor binding [IPI, ISO]
- RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription [ISO]
- beta-catenin binding [IPI]
- core promoter binding [IDA]
- core promoter proximal region sequence-specific DNA binding [ISO]
- double-stranded DNA binding [ISO]
- histone deacetylase binding [ISO]
- phosphatidylinositol 3-kinase regulator activity [ISO]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- sequence-specific DNA binding transcription factor recruiting transcription factor activity [IDA]
- transcription cofactor binding [ISO]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA, ISO]
- DNA binding [ISS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA, ISO]
- RNA polymerase II transcription factor binding [IPI, ISO]
- RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription [ISO]
- beta-catenin binding [IPI]
- core promoter binding [IDA]
- core promoter proximal region sequence-specific DNA binding [ISO]
- double-stranded DNA binding [ISO]
- histone deacetylase binding [ISO]
- phosphatidylinositol 3-kinase regulator activity [ISO]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- sequence-specific DNA binding transcription factor recruiting transcription factor activity [IDA]
- transcription cofactor binding [ISO]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA, ISO]
Gene Ontology Cellular Component
Mus musculus
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
ERK1 and ERK2 regulate embryonic stem cell self-renewal through phosphorylation of Klf4.
Understanding and controlling the mechanism by which stem cells balance self-renewal versus differentiation is of great importance for stem cell therapeutics. Klf4 promotes the self-renewal of embryonic stem cells, but the precise mechanism regulating this role of Klf4 is unclear. We found that ERK1 or ERK2 binds the activation domain of Klf4 and directly phosphorylates Klf4 at Ser123. This phosphorylation ... [more]
Nat. Struct. Mol. Biol. Feb. 05, 2012; 19(3);283-90 [Pubmed: 22307056]
Throughput
- Low Throughput
Additional Notes
- Source of MAPK1 not clear
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| KLF4 MAPK1 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | 2461110 |
Curated By
- BioGRID