BAIT
BMPR1A
10q23del, ACVRLK3, ALK3, CD292, SKR5
bone morphogenetic protein receptor, type IA
GO Process (9)
GO Function (6)
GO Component (2)
Gene Ontology Biological Process
- BMP signaling pathway [IDA, TAS]
- endocardial cushion formation [ISS]
- immune response [IMP]
- positive regulation of SMAD protein import into nucleus [IDA]
- positive regulation of bone mineralization [IMP]
- positive regulation of osteoblast differentiation [IMP]
- positive regulation of pathway-restricted SMAD protein phosphorylation [IDA]
- protein phosphorylation [IDA]
- transforming growth factor beta receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- caveola [IMP]
- plasma membrane [IDA, TAS]
Homo sapiens
PREY
TBK1
NAK, T2K
TANK-binding kinase 1
GO Process (17)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
- I-kappaB kinase/NF-kappaB signaling [TAS]
- MyD88-independent toll-like receptor signaling pathway [TAS]
- TRIF-dependent toll-like receptor signaling pathway [TAS]
- inflammatory response [TAS]
- innate immune response [TAS]
- negative regulation of type I interferon production [TAS]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IEP]
- positive regulation of interferon-alpha production [IDA]
- positive regulation of interferon-beta production [IDA]
- positive regulation of peptidyl-serine phosphorylation [NAS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of type I interferon production [TAS]
- response to virus [TAS]
- toll-like receptor 3 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
- type I interferon production [TAS]
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.
Genome-scale expression studies and comprehensive loss-of-function genetic screens have focused almost exclusively on the highest confidence candidate genes. Here, we describe a strategy for characterizing the lower confidence candidates identified by such approaches. We interrogated 177 genes that we classified as essential for the proliferation of cancer cells exhibiting constitutive β-catenin activity and integrated data for each of the candidates, ... [more]
Cell Syst Dec. 28, 2015; 3(3);302-316.e4 [Pubmed: 27684187]
Throughput
- High Throughput
Additional Notes
- High-credibility protein interactions were identified using draft-PPI and a method for protein interaction credibility scoring (ICS).
Curated By
- BioGRID