SHK1
Gene Ontology Biological Process
- Cdc42 protein signal transduction [IGI]
- cellular protein localization [IMP]
- establishment or maintenance of actin cytoskeleton polarity [TAS]
- establishment or maintenance of bipolar cell polarity regulating cell shape [IMP]
- positive regulation of establishment of bipolar cell polarity regulating cell shape [IGI]
- regulation of microtubule cytoskeleton organization [IGI]
- regulation of mitotic cytokinesis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ORB6
Gene Ontology Biological Process
- cellular response to osmotic stress [IMP]
- cortical actin cytoskeleton stabilization [IMP]
- establishment or maintenance of actin cytoskeleton polarity [IMP]
- establishment or maintenance of bipolar cell polarity regulating cell shape [IMP]
- fungal-type cell wall assembly [IMP]
- maintenance of protein location in cell cortex of cell tip [IMP]
- microtubule cytoskeleton organization [IMP]
- positive regulation of bipolar cell growth [IMP]
- regulation of G2/M transition of mitotic cell cycle [IGI]
- regulation of establishment or maintenance of bipolar cell polarity regulating cell shape [IGI, IMP]
- signal transduction [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Fission yeast orb6, a ser/thr protein kinase related to mammalian rho kinase and myotonic dystrophy kinase, is required for maintenance of cell polarity and coordinates cell morphogenesis with the cell cycle.
The molecular mechanisms that coordinate cell morphogenesis with the cell cycle remain largely unknown. We have investigated this process in fission yeast where changes in polarized cell growth are coupled with cell cycle progression. The orb6 gene is required during interphase to maintain cell polarity and encodes a serine/threonine protein kinase, belonging to the myotonic dystrophy kinase/cot1/warts family. A decrease ... [more]
Throughput
- Low Throughput
Ontology Terms
- inviable (APO:0000112)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SHK1 ORB6 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | PomBase | - |
Curated By
- BioGRID