DDX39B
Gene Ontology Biological Process
- ATP catabolic process [IDA, TAS]
- RNA secondary structure unwinding [IDA]
- RNA splicing [IDA]
- mRNA export from nucleus [IDA, IGI]
- mRNA splicing, via spliceosome [IGI]
- negative regulation of DNA damage checkpoint [IMP]
- positive regulation of DNA-templated transcription, elongation [IMP]
- spliceosomal complex assembly [IDA]
- viral mRNA export from host cell nucleus [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
MYH9
Gene Ontology Biological Process
- ATP catabolic process [IDA]
- actin cytoskeleton reorganization [IMP]
- actin filament-based movement [IDA]
- actomyosin structure organization [IDA]
- angiogenesis [IDA]
- axon guidance [TAS]
- blood vessel endothelial cell migration [IMP]
- cytokinesis [IMP]
- integrin-mediated signaling pathway [NAS]
- leukocyte migration [NAS]
- membrane protein ectodomain proteolysis [IDA]
- monocyte differentiation [IEP]
- platelet aggregation [IMP]
- platelet formation [IMP]
- protein transport [IMP]
- regulation of cell shape [IMP]
Gene Ontology Molecular Function- ADP binding [IDA]
- ATP binding [IDA]
- ATPase activity [IDA]
- actin binding [IDA]
- actin filament binding [IDA, NAS]
- actin-dependent ATPase activity [IDA]
- microfilament motor activity [IDA]
- motor activity [NAS]
- poly(A) RNA binding [IDA]
- protein anchor [IMP]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- ADP binding [IDA]
- ATP binding [IDA]
- ATPase activity [IDA]
- actin binding [IDA]
- actin filament binding [IDA, NAS]
- actin-dependent ATPase activity [IDA]
- microfilament motor activity [IDA]
- motor activity [NAS]
- poly(A) RNA binding [IDA]
- protein anchor [IMP]
- protein binding [IPI]
- protein homodimerization activity [IDA]
Gene Ontology Cellular Component
- COP9 signalosome [IDA]
- actin cytoskeleton [IDA]
- actomyosin [IDA]
- actomyosin contractile ring [IDA]
- cell leading edge [IDA]
- cleavage furrow [IDA]
- cytoplasm [IDA]
- cytosol [IDA]
- extracellular vesicular exosome [IDA]
- immunological synapse [IDA]
- integrin complex [IDA]
- membrane [IDA]
- myosin II complex [IDA]
- myosin II filament [IDA]
- nucleus [IDA]
- plasma membrane [IDA]
- protein complex [IDA]
- ruffle [IDA]
- stress fiber [IDA]
- uropod [IDA]
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.
Genome-scale expression studies and comprehensive loss-of-function genetic screens have focused almost exclusively on the highest confidence candidate genes. Here, we describe a strategy for characterizing the lower confidence candidates identified by such approaches. We interrogated 177 genes that we classified as essential for the proliferation of cancer cells exhibiting constitutive β-catenin activity and integrated data for each of the candidates, ... [more]
Throughput
- High Throughput
Additional Notes
- High-credibility protein interactions were identified using draft-PPI and a method for protein interaction credibility scoring (ICS).
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| DDX39B MYH9 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | - | |
| DDX39B MYH9 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | - | |
| DDX39B MYH9 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | - |
Curated By
- BioGRID