A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

Isolation and characterization of the fission yeast protein phosphatase gene ppe1+ involved in cell shape control and mitosis.

Shimanuki M, Kinoshita N, Ohkura H, Yoshida T, Toda T, Yanagida M

We isolated a fission yeast putative protein serine/threonine phosphatase gene designated ppe1+ by hybridization. The predicted amino acid sequence is similar to those of the fission yeast ppa2 (53% identity) and dis2 (39%) phosphatases, and highly similar to those of the budding yeast SIT4 (72%), Drosophila PPV (68%) and rabbit PPX (61%) phosphatases. Antibodies against ppe1 protein identified a 37-kd ... [more]

Mol. Biol. Cell Mar. 01, 1993; 4(3);303-13 [Pubmed: 8387356]

Throughput

Low Throughput

Ontology Terms

phenotype: inviable (APO:0000112)

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
PPE1 PPA2	Dosage Rescue Dosage Rescue A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene.	Shimanuki M (1993)	Low	-	BioGRID	677494

Curated By

BioGRID

Interaction Summary

PPE1

Gene Ontology Biological Process

Gene Ontology Molecular Function

phosphoprotein phosphatase activity [ISS]protein binding [IPI]

Gene Ontology Cellular Component

PPA2