A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

Deletion of Mia1/Alp7 activates Mad2-dependent spindle assembly checkpoint in fission yeast.

Sato M, Koonrugsa N, Toda T, Vardy L, Tournier S, Millar JB

... [more]

Nat. Cell Biol. Sep. 01, 2003; 5(9);764-6; author reply 766 [Pubmed: 12951601]

Throughput

Low Throughput

Ontology Terms

phenotype: inviable (APO:0000112)

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
ALP7 MAD2	Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.	Sato M (2003)	Low	-	BioGRID	246665
ALP7 MAD2	Synthetic Growth Defect Synthetic Growth Defect A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.	Tang NH (2015)	Low	-	BioGRID	2334539
ALP7 MAD2	Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.	Tang NH (2014)	Low	-	BioGRID	1022632

Curated By

BioGRID

Interaction Summary

ALP7

Gene Ontology Biological Process

Gene Ontology Molecular Function

protein binding [IPI]

Gene Ontology Cellular Component

MAD2