BAIT
RHO5
YNS0, Rho family GTPase RHO5, L000004798, YNL180C
Non-essential small GTPase of the Rho/Rac family of Ras-like proteins; regulated by phosphorylation and ubiquitination; likely involved in protein kinase C (Pkc1p)-dependent signal transduction pathway that controls cell integrity
GO Process (1)
GO Function (1)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
PREY
SCH9
HRM2, KOM1, serine/threonine protein kinase SCH9, L000001810, YHR205W
AGC family protein kinase; functional ortholog of mammalian S6 kinase; phosphorylated by Tor1p and required for TORC1-mediated regulation of ribosome biogenesis, translation initiation, and entry into G0 phase; involved in transactivation of osmostress-responsive genes; regulates G1 progression, cAPK activity and nitrogen activation of the FGM pathway; integrates nutrient signals and stress signals from sphingolipids to regulate lifespan
GO Process (11)
GO Function (1)
GO Component (4)
Gene Ontology Biological Process
- age-dependent response to oxidative stress involved in chronological cell aging [IMP]
- positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter [IMP]
- positive regulation of transcription from RNA polymerase I promoter [IGI, IMP]
- positive regulation of transcription from RNA polymerase III promoter [IGI, IMP]
- protein phosphorylation [IMP]
- regulation of cell size [IMP]
- regulation of protein localization [IMP]
- regulation of response to osmotic stress [IMP]
- regulation of sphingolipid biosynthetic process [IMP]
- regulation of transcription from RNA polymerase II promoter in response to oxidative stress [IMP]
- replicative cell aging [IMP]
Gene Ontology Molecular Function
Saccharomyces cerevisiae (S288c)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
The Small Yeast GTPase Rho5 and Its Dimeric GEF Dck1/Lmo1 Respond to Glucose Starvation.
Rho5 is a small GTPase of Saccharomyces cerevisiae and a homolog of mammalian Rac1. The latter regulates glucose metabolism and actin cytoskeleton dynamics, and its misregulation causes cancer and a variety of other diseases. In yeast, Rho5 has been implicated in different signal transduction pathways, governing cell wall integrity and the responses to high medium osmolarity and oxidative stress. It ... [more]
Int J Mol Sci Jul. 26, 2018; 19(8); [Pubmed: 30049968]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Curated By
- BioGRID