BAIT

PRP4

SPCC777.14
serine/threonine protein kinase Prp4
Schizosaccharomyces pombe (972h)
PREY

PRP5

cwf1, pi024, SPACTOKYO_453.10, SPBP22H7.07
WD repeat protein Prp5
GO Process (1)
GO Function (1)
GO Component (3)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Schizosaccharomyces pombe (972h)

Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

Fission yeast Prp4p kinase regulates pre-mRNA splicing by phosphorylating a non-SR-splicing factor.

Schwelnus W, Richert K, Opitz F, Gross T, Habara Y, Tani T, Kaeufer NF

We provide evidence that Prp4p kinase activity is required for pre-mRNA splicing in vivo and show that loss of activity impairs G1-S and G2-M progression in the cell cycle. Prp4p interacts genetically with the non-SR (serine/arginine) splicing factors Prp1p and Prp5p. Bacterially produced Prp1p is phosphorylated by Prp4p in vitro. Prp4p and Prp1p also interact in the yeast two-hybrid system. ... [more]

EMBO Rep. Jan. 01, 2001; 2(1);35-41 [Pubmed: 11252721]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: inviable (APO:0000112)

Curated By

  • BioGRID