MYD88
Gene Ontology Biological Process
- 3'-UTR-mediated mRNA stabilization [IDA]
- MyD88-dependent toll-like receptor signaling pathway [TAS]
- cell surface receptor signaling pathway [TAS]
- cellular response to mechanical stimulus [IEP]
- defense response to Gram-positive bacterium [ISS]
- innate immune response [TAS]
- negative regulation of apoptotic process [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IEP]
- positive regulation of interleukin-17 production [ISS]
- positive regulation of interleukin-23 production [ISS]
- positive regulation of interleukin-6 production [ISS]
- positive regulation of type I interferon production [TAS]
- regulation of inflammatory response [ISS]
- response to interleukin-1 [IMP]
- signal transduction [NAS]
- toll-like receptor 10 signaling pathway [TAS]
- toll-like receptor 2 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor 5 signaling pathway [TAS]
- toll-like receptor 9 signaling pathway [TAS]
- toll-like receptor TLR1:TLR2 signaling pathway [TAS]
- toll-like receptor TLR6:TLR2 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
TSG101
Gene Ontology Biological Process
- endosomal transport [TAS]
- intracellular transport of virus [TAS]
- membrane organization [TAS]
- positive regulation of exosomal secretion [IMP]
- regulation of extracellular vesicular exosome assembly [IMP]
- ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [IC, IDA, IMP]
- viral budding [IMP, ISS]
- viral life cycle [TAS]
- viral process [TAS]
- viral protein processing [TAS]
- virion assembly [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
A Pseudomonas aeruginosa TIR effector mediates immune evasion by targeting UBAP1 and TLR adaptors.
Bacterial pathogens often subvert the innate immune system to establish a successful infection. The direct inhibition of downstream components of innate immune pathways is particularly well documented but how bacteria interfere with receptor proximal events is far less well understood. Here, we describe a Toll/interleukin 1 receptor (TIR) domain-containing protein (PumA) of the multi-drug resistant Pseudomonas aeruginosa PA7 strain. We ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID