BAIT
NCOA1
KAT13A, SRC-1, SRC1, bHLHe74
nuclear receptor coactivator 1
GO Process (18)
GO Function (16)
GO Component (4)
Gene Ontology Biological Process
- cellular response to hormone stimulus [IBA, ISO]
- histone H4 acetylation [IMP]
- intracellular receptor signaling pathway [IBA]
- labyrinthine layer morphogenesis [IGI]
- male mating behavior [ISO]
- positive regulation of apoptotic process [IMP]
- positive regulation of female receptivity [ISO]
- positive regulation of neuron differentiation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, ISO]
- positive regulation of transcription from RNA polymerase II promoter by galactose [IMP, ISO]
- positive regulation of transcription, DNA-templated [ISO]
- regulation of RNA biosynthetic process [IMP]
- regulation of cellular response to drug [IMP]
- regulation of nucleic acid-templated transcription [IBA]
- response to estradiol [ISO]
- response to progesterone [ISO]
- response to retinoic acid [ISO]
- transcription, DNA-templated [ISO]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA polymerase II regulatory region DNA binding [ISO]
- chromatin binding [IDA]
- enzyme binding [ISO]
- estrogen receptor binding [ISO]
- ligand-dependent nuclear receptor binding [IBA, ISO]
- ligand-dependent nuclear receptor transcription coactivator activity [IBA, ISO]
- nuclear hormone receptor binding [IBA, ISO]
- progesterone receptor binding [ISO]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- retinoic acid receptor binding [ISO]
- retinoid X receptor binding [ISO]
- transcription coactivator activity [IDA, IMP, ISO]
- transcription factor binding [IPI, ISO]
- DNA binding [IDA]
- RNA polymerase II regulatory region DNA binding [ISO]
- chromatin binding [IDA]
- enzyme binding [ISO]
- estrogen receptor binding [ISO]
- ligand-dependent nuclear receptor binding [IBA, ISO]
- ligand-dependent nuclear receptor transcription coactivator activity [IBA, ISO]
- nuclear hormone receptor binding [IBA, ISO]
- progesterone receptor binding [ISO]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- retinoic acid receptor binding [ISO]
- retinoid X receptor binding [ISO]
- transcription coactivator activity [IDA, IMP, ISO]
- transcription factor binding [IPI, ISO]
Gene Ontology Cellular Component
Mus musculus
PREY
VDR
Nr1i1
vitamin D receptor
GO Process (27)
GO Function (12)
GO Component (15)
Gene Ontology Biological Process
- apoptotic signaling pathway [ISO]
- bile acid signaling pathway [ISO]
- calcium ion transport [IMP]
- cell morphogenesis [ISO]
- cellular calcium ion homeostasis [IMP]
- intestinal absorption [IMP]
- intracellular receptor signaling pathway [IDA]
- lactation [IMP]
- mammary gland branching involved in pregnancy [IMP]
- multicellular organismal development [IMP]
- negative regulation of cell proliferation [ISO]
- negative regulation of keratinocyte proliferation [ISO]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- negative regulation of transcription, DNA-templated [ISO]
- organ morphogenesis [IMP]
- positive regulation of apoptotic process involved in mammary gland involution [IMP]
- positive regulation of gene expression [ISO]
- positive regulation of keratinocyte differentiation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of vitamin D 24-hydroxylase activity [ISO]
- regulation of calcidiol 1-monooxygenase activity [IMP]
- regulation of calcium ion transport [ISO]
- regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of transcription, DNA-templated [IDA]
- skeletal system development [IMP]
- transcription from RNA polymerase II promoter [IDA]
- vitamin D receptor signaling pathway [ISO]
Gene Ontology Molecular Function- DNA binding [IDA, ISO]
- calcitriol binding [ISO]
- calcitriol receptor activity [ISO]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- lithocholic acid binding [ISO]
- lithocholic acid receptor activity [ISO]
- protein binding [IPI]
- retinoid X receptor binding [ISO]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [ISO]
- vitamin D binding [ISO]
- vitamin D response element binding [ISO]
- DNA binding [IDA, ISO]
- calcitriol binding [ISO]
- calcitriol receptor activity [ISO]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- lithocholic acid binding [ISO]
- lithocholic acid receptor activity [ISO]
- protein binding [IPI]
- retinoid X receptor binding [ISO]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [ISO]
- vitamin D binding [ISO]
- vitamin D response element binding [ISO]
Gene Ontology Cellular Component
- RNA polymerase II transcription factor complex [ISO]
- T-tubule [ISO]
- caveola [ISO]
- cell [IMP]
- cytosol [ISO]
- dense fibrillar component [ISO]
- euchromatin [ISO]
- heterochromatin [ISO]
- intracellular membrane-bounded organelle [ISO]
- nuclear heterochromatin [ISO]
- nuclear matrix [ISO]
- nucleoplasm [ISO]
- nucleus [ISO]
- perinuclear region of cytoplasm [ISO]
- receptor complex [ISO]
Mus musculus
Co-localization
Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.
Publication
p62/SQSTM1 by Binding to Vitamin D Receptor Inhibits Hepatic Stellate Cell Activity, Fibrosis, and Liver Cancer.
Hepatic stellate cells (HSCs) play critical roles in liver fibrosis and hepatocellular carcinoma (HCC). Vitamin D receptor (VDR) activation in HSCs inhibits liver inflammation and fibrosis. We found that p62/SQSTM1, a protein upregulated in liver parenchymal cells but downregulated in HCC-associated HSCs, negatively controls HSC activation. Total body or HSC-specific p62 ablation potentiates HSCs and enhances inflammation, fibrosis, and HCC ... [more]
Cancer Cell Dec. 10, 2015; 30(4);595-609 [Pubmed: 27728806]
Throughput
- Low Throughput
Additional Notes
- proximity ligation assay
Related interactions
Curated By
- BioGRID