BAIT
VDR
Nr1i1
vitamin D receptor
GO Process (27)
GO Function (12)
GO Component (15)
Gene Ontology Biological Process
- apoptotic signaling pathway [ISO]
- bile acid signaling pathway [ISO]
- calcium ion transport [IMP]
- cell morphogenesis [ISO]
- cellular calcium ion homeostasis [IMP]
- intestinal absorption [IMP]
- intracellular receptor signaling pathway [IDA]
- lactation [IMP]
- mammary gland branching involved in pregnancy [IMP]
- multicellular organismal development [IMP]
- negative regulation of cell proliferation [ISO]
- negative regulation of keratinocyte proliferation [ISO]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- negative regulation of transcription, DNA-templated [ISO]
- organ morphogenesis [IMP]
- positive regulation of apoptotic process involved in mammary gland involution [IMP]
- positive regulation of gene expression [ISO]
- positive regulation of keratinocyte differentiation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of vitamin D 24-hydroxylase activity [ISO]
- regulation of calcidiol 1-monooxygenase activity [IMP]
- regulation of calcium ion transport [ISO]
- regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of transcription, DNA-templated [IDA]
- skeletal system development [IMP]
- transcription from RNA polymerase II promoter [IDA]
- vitamin D receptor signaling pathway [ISO]
Gene Ontology Molecular Function- DNA binding [IDA, ISO]
- calcitriol binding [ISO]
- calcitriol receptor activity [ISO]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- lithocholic acid binding [ISO]
- lithocholic acid receptor activity [ISO]
- protein binding [IPI]
- retinoid X receptor binding [ISO]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [ISO]
- vitamin D binding [ISO]
- vitamin D response element binding [ISO]
- DNA binding [IDA, ISO]
- calcitriol binding [ISO]
- calcitriol receptor activity [ISO]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- lithocholic acid binding [ISO]
- lithocholic acid receptor activity [ISO]
- protein binding [IPI]
- retinoid X receptor binding [ISO]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [ISO]
- vitamin D binding [ISO]
- vitamin D response element binding [ISO]
Gene Ontology Cellular Component
- RNA polymerase II transcription factor complex [ISO]
- T-tubule [ISO]
- caveola [ISO]
- cell [IMP]
- cytosol [ISO]
- dense fibrillar component [ISO]
- euchromatin [ISO]
- heterochromatin [ISO]
- intracellular membrane-bounded organelle [ISO]
- nuclear heterochromatin [ISO]
- nuclear matrix [ISO]
- nucleoplasm [ISO]
- nucleus [ISO]
- perinuclear region of cytoplasm [ISO]
- receptor complex [ISO]
Mus musculus
PREY
NCOA1
KAT13A, SRC-1, SRC1, bHLHe74
nuclear receptor coactivator 1
GO Process (18)
GO Function (16)
GO Component (4)
Gene Ontology Biological Process
- cellular response to hormone stimulus [IBA, ISO]
- histone H4 acetylation [IMP]
- intracellular receptor signaling pathway [IBA]
- labyrinthine layer morphogenesis [IGI]
- male mating behavior [ISO]
- positive regulation of apoptotic process [IMP]
- positive regulation of female receptivity [ISO]
- positive regulation of neuron differentiation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, ISO]
- positive regulation of transcription from RNA polymerase II promoter by galactose [IMP, ISO]
- positive regulation of transcription, DNA-templated [ISO]
- regulation of RNA biosynthetic process [IMP]
- regulation of cellular response to drug [IMP]
- regulation of nucleic acid-templated transcription [IBA]
- response to estradiol [ISO]
- response to progesterone [ISO]
- response to retinoic acid [ISO]
- transcription, DNA-templated [ISO]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA polymerase II regulatory region DNA binding [ISO]
- chromatin binding [IDA]
- enzyme binding [ISO]
- estrogen receptor binding [ISO]
- ligand-dependent nuclear receptor binding [IBA, ISO]
- ligand-dependent nuclear receptor transcription coactivator activity [IBA, ISO]
- nuclear hormone receptor binding [IBA, ISO]
- progesterone receptor binding [ISO]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- retinoic acid receptor binding [ISO]
- retinoid X receptor binding [ISO]
- transcription coactivator activity [IDA, IMP, ISO]
- transcription factor binding [IPI, ISO]
- DNA binding [IDA]
- RNA polymerase II regulatory region DNA binding [ISO]
- chromatin binding [IDA]
- enzyme binding [ISO]
- estrogen receptor binding [ISO]
- ligand-dependent nuclear receptor binding [IBA, ISO]
- ligand-dependent nuclear receptor transcription coactivator activity [IBA, ISO]
- nuclear hormone receptor binding [IBA, ISO]
- progesterone receptor binding [ISO]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- retinoic acid receptor binding [ISO]
- retinoid X receptor binding [ISO]
- transcription coactivator activity [IDA, IMP, ISO]
- transcription factor binding [IPI, ISO]
Gene Ontology Cellular Component
Mus musculus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Thr176 regulates the activity of the mouse nuclear receptor CAR and is conserved in the NR1I subfamily members PXR and VDR.
The mouse nuclear receptor CAR (constitutively active receptor) is a transcription factor that is activated by phenobarbital-type inducers such as TCPOBOP {1,4 bis[2-(3,5-dichloropyridyloxy)]benzene} in liver in vivo. However, CAR is constitutively active in cell-based transfection assays, the molecular mechanism for which has not been elucidated yet. In the model structure of CAR, Thr176 constitutes a part of the ligand-binding surface, ... [more]
Biochem. J. Jun. 01, 2005; 388(0);623-30 [Pubmed: 15610065]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| NCOA1 VDR | Co-localization Co-localization Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments. | Low | - | BioGRID | 2470368 |
Curated By
- BioGRID