BAIT
DIS2
bws1, sds1, SPBC776.02c
serine/threonine protein phosphatase PP1 subfamily, Dis2
GO Process (7)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
- mitotic DNA damage checkpoint [IGI]
- mitotic sister chromatid segregation [IMP]
- positive regulation of establishment of cell polarity regulating cell shape [EXP]
- positive regulation of protein localization to cell tip [EXP]
- rRNA processing [ISO]
- regulation of mitotic sister chromatid segregation [IMP]
- signal transduction [NAS]
Gene Ontology Molecular Function
Schizosaccharomyces pombe (972h)
PREY
DIS3
rrp44, SPBC26H8.10
3'-5' exoribonuclease subunit Dis3
GO Process (12)
GO Function (5)
GO Component (4)
Gene Ontology Biological Process
- RNA phosphodiester bond hydrolysis, endonucleolytic [ISO]
- exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [ISO]
- exonucleolytic trimming to generate mature 5'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [ISO]
- mitotic sister chromatid segregation [IMP]
- ncRNA catabolic process [ISO]
- nonfunctional rRNA decay [ISO]
- nuclear polyadenylation-dependent mRNA catabolic process [ISO]
- nuclear polyadenylation-dependent rRNA catabolic process [ISO]
- nuclear polyadenylation-dependent tRNA catabolic process [ISO]
- nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [ISO]
- nuclear-transcribed mRNA catabolic process, non-stop decay [ISO]
- positive regulation of Ran GTPase activity [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
The fission yeast dis3+ gene encodes a 110-kDa essential protein implicated in mitotic control.
The fission yeast mutant dis3-54 is defective in mitosis and fails in chromosome disjunction. Its phenotype is similar to that of dis2-11, a mutant with a mutation in the type 1 protein phosphatase gene. We cloned the dis3+ gene by transformation. Nucleotide sequencing predicts a coding region of 970 amino acids interrupted by a 164-bp intron at the 65th codon. ... [more]
Mol. Cell. Biol. Dec. 01, 1991; 11(12);5839-47 [Pubmed: 1944266]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Curated By
- BioGRID