PDE4B
Gene Ontology Biological Process
- T cell receptor signaling pathway [IMP]
- cAMP catabolic process [IDA, IGI]
- cellular response to drug [ISS]
- cellular response to epinephrine stimulus [ISS]
- cellular response to lipopolysaccharide [ISS]
- leukocyte migration [ISS]
- negative regulation of relaxation of cardiac muscle [ISS]
- neutrophil chemotaxis [ISS]
- neutrophil homeostasis [ISS]
- positive regulation of interferon-gamma production [IMP]
- positive regulation of interleukin-2 production [IMP]
- regulation of cardiac muscle cell contraction [ISS]
- regulation of high voltage-gated calcium channel activity [ISS]
Gene Ontology Molecular Function
SMURF2
Gene Ontology Biological Process
- BMP signaling pathway [TAS]
- gene expression [TAS]
- negative regulation of transcription from RNA polymerase II promoter [TAS]
- negative regulation of transcription, DNA-templated [NAS]
- negative regulation of transforming growth factor beta receptor signaling pathway [TAS]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IBA]
- regulation of transforming growth factor beta receptor signaling pathway [NAS]
- transcription initiation from RNA polymerase II promoter [TAS]
- transcription, DNA-templated [TAS]
- transforming growth factor beta receptor signaling pathway [IBA, TAS]
- ubiquitin-dependent SMAD protein catabolic process [IDA]
- ubiquitin-dependent protein catabolic process [IDA]
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Smurf2, an E3 ubiquitin ligase, interacts with PDE4B and attenuates liver fibrosis through miR-132 mediated CTGF inhibition.
We previously reported that Smad ubiquitin regulatory factor 2 (Smurf2) activity was decreased in human fibrotic livers. Here, we overexpressed Smurf2 in livers of transgenic mice and observed inhibited collagen deposition and hepatic stellate cell activation in fibrotic model induced by carbon tetrachloride treatment or bile duct ligation. Hepatic Smurf2 overexpression also inhibited the production of connective tissue growth factor ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SMURF2 PDE4B | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| SMURF2 PDE4B | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - |
Curated By
- BioGRID